RT info:eu-repo/semantics/article
T1 Synthesis and structure of new pyrido[2,3-D]pyrimidine derivatives with calcium-channel antagonist activity
A1 Pastor del Castillo, Alfredo
A1 Alajarín Ferrández, Luis Ramón
A1 Vaquero López, Juan J.
A1 Álvarez-Builla Gómez, Julio
A1 Casa-Juana Muñoz, Miguel Fau de
A1 Sunkel Letelier, Carlos
A1 Priego, J.G.
A1 Fonseca, I.
A1 Sanz-Aparicio, Julia
K1 Pyrido[2,3-D]pyrimidine derivatives
K1 Calcium-channel
K1 Ciencia
K1 Química orgánica
K1 Science
K1 Chemistry, organic
AB Several series of pyrido[2,3-d]pyrimidine derivatives were synthesized by reaction of aryl methyleneacetoacetates with different aminopyrimidines. The solid-state structure of the methyl 5-(3'-chlorophenyl)-7-methyl-4-oxo-2-thioxo-1,2,3,4,5,8-hexahydropyrido[ 2,3-d]pyrimidine-6-carboxylate shows that these compounds can adopt some of the most important structural features of the 1,4-dihydropyridine calcium channel blockers. The scope and limitations of the synthetic procedure with different aminoheterocycles is presented together with the initial evaluation of their calcium antagonistic activity by comparison with the usual reference compound nifedipine.
PB Pergamon
SN 0040-4020
YR 1994
FD 1994
LK http://hdl.handle.net/10017/3697
UL http://hdl.handle.net/10017/3697
LA eng
NO We gratefully acknowledge to ALTER S. A. for studentship (to A. P and R. A.) and financial support
DS MINDS@UW
RD 24-abr-2024