RT info:eu-repo/semantics/article
T1 New bow-tie cationic carbosilane dendritic system with a curcumin core as an anti-breast cancer agent
A1 Ortega Lopez, Paula
A1 Mata de la Mata, Francisco Javier de la
A1 Gómez Ramírez, Rafael
A1 Lozano de la Cruz, Tania
K1 curcumin
K1 dendrimers
K1 carbosilane, MCF-7
K1 Antioxidant, antitumoral
K1 Química
K1 Chemistry
AB Though curcumin has been demonstrated as highly cytotoxic towards various cancer cell lines, the major drawbacks for its use are the insolubility and instability in water to provoke low bioavailability. On the other hand, carbosilane dendritic systems with cationic charge on the surface have been studied in different biomedical applications such as antibacterial, anticancer or as non-viral vehicles for the delivery of nucleic acids. In this study, we combine both systems by synthesizing a new "bow-tie" cationic carbosilane dendrimer where curcumin is located at the core. The resulting new system is completely water-soluble, conserves the antioxidant properties and induces higher cytotoxicity against MCF-7 cancer cells than free curcumin. In addition, the effects on the cell cycle and apoptosis induction by using flow cytometry analysis are evaluated to obtain insights of the cytotoxic mechanism of action.
SN 1144-0546
YR 2018
FD 2018
LK http://hdl.handle.net/10017/35920
UL http://hdl.handle.net/10017/35920
LA eng
DS MINDS@UW
RD 24-abr-2024