RT info:eu-repo/semantics/article
T1 Synthesis of chiral carbosilane dendrimers with L-cysteine and N-acetyl-L-cysteine on their surface and their application as chiral selectors for enantiomer separation by capillary electrophoresis
A1 Quintana Sánchez, Sara
A1 Ortega Lopez, Paula
A1 Mata de la Mata, Francisco Javier de la
A1 Gómez Ramírez, Rafael
A1 Marina Alegre, María Luisa
A1 García González, María Ángeles
K1 carbosilane
K1 dendrimers
K1 chiral
K1 electrophoresis
K1 Química
K1 Chemistry
AB The synthesis of chiral carbosilane dendrimers functionalized with cysteine and Nacetylcysteine groups is presented in this work. These dendrimers were obtained through thiol-ene addition reactions and their application as chiral selectors in Capillary Electrophoresis was investigated. Four drugs used as model compounds were analyzed under different experimental conditions observing that the use of a first generation dendrimer containing 4 terminal N-Acetyl-L-cysteine groups enabled the enantiomeric discrimination of razoxane being this discrimination power similar to that obtained with other powerful chiral selectors such as cyclodextrins.
SN 0957-4166
YR 2017
FD 2017-12-15
LK http://hdl.handle.net/10017/35870
UL http://hdl.handle.net/10017/35870
LA eng
DS MINDS@UW
RD 20-abr-2024