RT info:eu-repo/semantics/article
T1 Improved efficiency of ibuprofen by cationic carbosilane dendritic conjugates
A1 Perise-Barrios, A.J.
A1 Fuentes Paniagua, María Elena
A1 Sánchez-Nieves Fernández, Javier
A1 Serramía  Lobera, Mª Jesús
A1 Alonso, Ester
A1 Reguera, Rosa
A1 Gómez Ramírez, Rafael
A1 Mata de la Mata, Francisco Javier de la
A1 Muñoz Fernández, María Ángeles
K1 Anti-inflammatory
K1 Carbosilane dendrimers,
K1 Dendrons
K1 Ibuprofen
K1 Drug release and macrophages.
K1 Química
K1 Chemistry
AB In order to improve the efficiency of the anti-inflammatory drug ibuprofen, cationic carbosilanedendrimers and dendrons with ibuprofen at their periphery or at their focal point, respectively, havebeen synthesized and the release of the drug was studied using HPLC. Macrophages were used toevaluate the anti-inflammatory effect of the ibuprofen-conjugated dendritic systems and comparedwith mixtures of non-ibuprofen dendritic systems in the presence of the drug. The cationic ibuprofenconjugateddendron was the compound that showed higher anti-inflammatory properties. It reduces the LPS-induced COX-2 expression, decreases the release of several inflammatory cytokines such as TNFalfa, IL-1beta, IL-6 and CCL3. These results open new perspectives in the use of these compounds asdrug carriers.
PB American Chemical Society
SN 1543-8384
YR 2016
FD 2016-08-17
LK http://hdl.handle.net/10017/34041
UL http://hdl.handle.net/10017/34041
LA eng
NO Ministerio de Economía y Empresa
DS MINDS@UW
RD 26-abr-2024