RT info:eu-repo/semantics/preprint
T1 Carbosilane cationic dendrimers synthesized by thiol-ene chemistry and their use as antibacterial agents
A1 Fuentes Paniagua, María Elena
A1 Hernández Ros, José Manuel
A1 Sánchez Milla, María
A1 Camero, M. Alejandra
A1 Maly, Marek
A1 Pérez Serrano, Jorge
A1 Copa Patiño, José Luis
A1 Sánchez-Nieves Fernández, Javier
A1 Soliveri de Carranza, Juan
A1 Gómez Ramírez, Rafael
A1 Mata de la Mata, Francisco Javier de la
K1 Cationic carbosilane dendrimers
K1 Sulfur atom
K1 Química
K1 Chemistry
AB + in dendrimer structure have been studied by molecular dynamics. The antibacterial properties of these families of dendrimers have been evaluated against Gram-positive (Staphylococcus aureus CECT 240) and Gram-negative (Escherichia coli CECT 515) bacterial strains, and the results obtained have been compared with those obtained for related cationic carbosilane dendrimers functionalized by hydrosilylation reactions. These data stand out the relevance of the sulfur atom versus the silicon atom close to the dendrimer surface and the outer charge versus the inner charge. Finally, the stability of the most active first generation dendrimers vs. pH and temperature has also been studied.
PB Royal Society of Chemistry,
SN 2046-2069
YR 2014
FD 2014-01-01
LK http://hdl.handle.net/10017/33981
UL http://hdl.handle.net/10017/33981
LA eng
NO Ministerio de Economía y Empresa
DS MINDS@UW
RD 19-abr-2024