RT info:eu-repo/semantics/article
T1 Prognostic value of inhibitors of apoptosis proteins (IAPs) and caspases in prostate cancer: caspase-3 forms and XIAP predict biochemical progression after radical prostatectomy
A1 Rodríguez Berriguete, Gonzalo
A1 Ortega Núñez, Miguel Ángel
A1 Torrealba Abache, Norelia Rosa
A1 Martínez Onsurbe, María del Pilar
A1 Olmedilla Arregui, Gabriel
A1 Paniagua Gómez-Álvarez, Ricardo
A1 Guil Cid, Manuel Esteban
A1 Fraile Laiz, Benito
A1 Royuela García, María del Mar
K1 Apoptosis
K1 Caspases
K1 Biochemical progression
K1 Inhibitors of apoptosis proteins
K1 Prostate cancer
K1 Biología
K1 Biology
K1 Genética
K1 Genetics
K1 Ciencia
K1 Science
K1 Aged
K1 Biomarkers, Tumor
K1 Caspase 3
K1 Cohort Studies
K1 Disease Progression
K1 Follow-Up Studies
K1 Humans
K1 Inhibitor of Apoptosis Proteins
K1 Male
K1 Middle Aged
K1 Predictive Value of Tests
K1 Prognosis
K1 Prostatectomy
K1 Prostatic Neoplasms
K1 X-Linked Inhibitor of Apoptosis Protein
AB Background: The expression status of apoptotic regulators, such as caspases and inhibitors of apoptosis proteins (IAPs), could reflect the aggressiveness of tumors and, therefore, could be useful as prognostic markers. We explored the associations between tumor expression of caspases and IAPs and clinicopathological features of prostate cancer – clinical and pathological T stage, Gleason score, preoperative serum PSA levels, perineural invasion, lymph node involvement, surgical margin status and overall survival – and evaluated its capability to predict biochemicalprogression after radical prostatectomy.Methods: Protein expression of caspases (procaspase-8, cleaved caspase-8, procaspase-3, cleaved caspase-3,caspase-7 and procaspase-9) and IAPs (cIAP1/2, cIAP2, NAIP, Survivin and XIAP) was analyzed by immunohistochemistryin radical prostatectomy samples from 84 prostate cancer patients. Spearman’s test, Kaplan-Meier curves, and univariateand multivariate Cox proportional hazard regression analysis were performed.Results: cIAP1/2, cIAP2, Survivin, procaspase-8, cleaved caspase-8, procaspase-3 and caspase-7 expression correlatedwith at least one clinicopathological feature of the disease. Patients negative for XIAP, procaspase-3 or cleavedcaspase-3 had a significantly worse prognosis. Of note, XIAP, procaspase-3 and cleaved caspase-3 were predictorsof biochemical progression independent of Gleason score and pathological T stage.Conclusions: Our results indicate that alterations in the expression of IAPs and caspases contribute to themalignant behavior of prostate tumors and suggest that tumor expression of XIAP, procaspase-3 and cleavedcaspase-3 may help to identify prostate cancer patients at risk of progression.
PB BioMed Central
YR 2015
FD 2015
LK http://hdl.handle.net/10017/32720
UL http://hdl.handle.net/10017/32720
LA eng
DS MINDS@UW
RD 30-nov-2023