RT info:eu-repo/semantics/article
T1 Activation of D1 and D2 dopamine receptors increases the activity of the somatostatin receptor-effector system in the rat frontoparietal cortex
A1 Izquierdo Claros, Rosa María
A1 Boyano Adánez, María del Carmen
A1 Arilla Ferreiro, Eduardo
K1 SKF 38393
K1 Bromocriptine
K1 SCH 23390
K1 Raclopride
K1 Somatostatin receptor
K1 Adenylyl cyclase
K1 Inositol-1,4,5-triphosphate
K1 Rat
K1 Frontoparietal cortex
K1 Bioquímica
K1 Biochemistry
K1 Science
K1 Ciencia
AB The role of dopamine D1 and D2 receptor subtypes in the regulation, in vivo, of the somatostatin (SRIF) receptor-effector system in rat frontoparietal cortex was investigated. The D1-receptor agonist SKF 38393 (4 mg/kg) or the D2-receptor agonist bromocriptine (2 mg/kg), administered intraperitoneally to rats, increased the number of SRIF receptors without altering the affinity constant, an effect antagonized by both SCH 23390 (0.25 mg/kg) and raclopride (5 mg/kg), D1 and D2 receptor antagonists, respectively. These antagonists alone had no effect on [125I]Tyr3 octreotide binding to its receptors. No change in binding was detected when the dopamine agonists were added in vitro. Basal adenylyl cyclase (AC) activity was increased by SKF 38393 treatment and decreased by bromocriptine. Octreotide (SMS 201-995)-mediated inhibition of basal and forskolin-stimulated AC was increased by SKF 38393 or bromocriptine treatment. In frontoparietal cortical slices, basal inositol-1,4,5-triphosphate (IP3) levels were decreased by bromocriptine treatment but were unaffected by SKF 38393. SMS 201-995 increased the IP3 accumulation in control, SKF 38393-, and bromocriptine-treated rats. Insofar as SRIF and dopamine appear to be involved in motor regulation and could well modulate somatosensory functions in frontal and parietal cortex, respectively, heterologous receptor regulation may have important repercussions regarding the control exerted by these neurotransmitters on frontal and parietal cortical function in the intact animal. J. Neurosci. Res. 62:91–98, 2000. © 2000 Wiley-Liss, Inc.
PB Wiley-Liss
SN 1097-4547
YR 2000
FD 2000
LK http://hdl.handle.net/10017/2977
UL http://hdl.handle.net/10017/2977
LA eng
NO We thank Martin Lexell from Centro de Lenguas Extranjeras of the Universidad de Alcala´, Angela Martı´n Espinosa for her excellent technical assistance, and Lilian Puebla and Jerry Keller for their linguistic assistance. We express our sincere thanks to Astra Ifesa (Barcelona, Spain) for the supply of raclopride and to Sandoz (Basel, Switzerland) for the supply of SMS 201-995 and SDZ 204- 090.
DS MINDS@UW
RD 16-abr-2024