RT info:eu-repo/semantics/article T1 Selective palladium-catalyzed amination of the heterocyclic core of variolins A1 Baeza García, Alejandro A1 Burgos García, Carolina A1 Álvarez-Builla Gómez, Julio A1 Vaquero López, Juan J. K1 Pyrido[3 ',3 ': 4,5]pyrrolo[1,2-c]pyrimidine K1 N-tosylmethyl dichloroformimide K1 Amination K1 Palladium-catalyzed K1 Variolins K1 Sponge kirkpatrickia-varialosa K1 Tosylmethyl isocyanide K1 Alkaloids K1 Deoxyvariolin-B K1 Azolopyrimidines K1 Meridianins K1 Derivatives K1 Chlorides K1 Oxazoles K1 Bromides K1 Chemistry, Organic K1 Bioquímica K1 Biochemistry K1 Science K1 Ciencia AB A new and selective palladium-catalyzed amination of the pyrido[3′,3′:4,5]pyrrolo[1,2-c]pyrimidine nucleus, the heterocyclic core of the variolin alkaloids, is described. The method allows the introduction of amino and aryl- and alkylamino substituents on the C9 position in advanced precursors of variolin B and deoxyvariolin. PB Elsevier SN 0040-4039 YR 2007 FD 2007 LK http://hdl.handle.net/10017/2652 UL http://hdl.handle.net/10017/2652 LA eng NO We acknowledge financial support from the Spanish Ministerio de Educación y Ciencia (project CTQ2005/011060), Comunidad de Madrid (CAM) and Universidad de Alcalá (UAH) (project CAM/UAH-2005/044) and a grant (A.B.) from the Ministerio de Educación y Ciencia. DS MINDS@UW RD 29-mar-2024