RT info:eu-repo/semantics/article
T1 Brain somatostatinergic system at late pregnancy, parturition and the early postpartum period in the rat
A1 Barrios Sabador, Vicente
A1 Puebla Jiménez, Lilian
A1 Rodríguez Sánchez, María Nelly
A1 Arilla Ferreiro, Eduardo
K1 Frontoparietal cortex
K1 Hippocampus
K1 Pregnancy
K1 Rat
K1 Somatostatin receptor
K1 Pregnancy
K1 Somaiostatin receptor
K1 Frontoparietal cortex
K1 Hippocampus
K1 Rat
K1 Bioquímica
K1 Biochemistry
K1 Science
K1 Ciencia
AB During pregnancy and postpartum rats experience a wide varietv of behavioural changes. Since the soma-tostatinergic system has been iraplicated in the control of some of these changes, the present study examined somatostatin (SS) content and specific binding in the frontoparietal cortex and hippocampus of non-pregnant. pregnant (17 to 18 days), parturition and postpartum (10 and 30 days) rats as well as in ovariectomized rats which were or were not treated with estradiol valerianate. The content of somatostatin-like inimunoreactivity (SSLI) was increased at 17 days of pregnancy in frontoparietal cortex and decreased at parturition and 10 days postpartum in that región and the hippocampus under study when compared with SSLI levels in non-pregnant rats. At 30 days postpartum the SSLI content returned to non-pregnant valúes in both brain regions. Scatchard analysis showed that the decrease in [125I]Tyru-SS binding observed at 17 days of pregnancy in the frontoparietal cortex was due to the decrease in the number of SS receptors. In contrast, on the dav of delivery the number of SS receptors in the same brain región increased. The affinity of the SS receptors was consistently unchanged in pregnant and non-pregnant rats in both regions. At 10 days postpartum the valué of specific binding of the tracer to SS receptors in the frontoparietal cortex was not significantly different from that in the non-pregnant rats, although the actual number of receptors was slightly higher. Pregnancy did not change SS binding in the hippocampus. Neither ovariectomy ñor the treatment of ovariectomized rats with estradiol valerianate affected cortical and hippocampal SS content and binding in the rats. These changes in the somatostatinergic system associated with late pregnancy, parturition and the earlv postpartum period may well be important because of their possible role in some of the behavioural changes observed during these periods.
PB Elsevier
SN 0167-0115
YR 1993
FD 1993
LK http://hdl.handle.net/10017/2481
UL http://hdl.handle.net/10017/2481
LA eng
NO Ministerio de Educación y Ciencia
DS MINDS@UW
RD 24-abr-2024