RT info:eu-repo/semantics/article
T1 Effects of acute nicotine and mecamylamine administration on somatostatin concentration and binding in the rat brain
A1 Barrios Sabador, Vicente
A1 Rodríguez Sánchez, María Nelly
A1 Colás Escudero, María Begoña
A1 Arilla Ferreiro, Eduardo
K1 Rat
K1 Brain
K1 Mecamylamine
K1 Nicotine
K1 Somatostatin receptors
K1 Bioquímica
K1 Biochemistry
K1 Science
K1 Ciencia
AB Since nicotine and somatostin have regulatory effects on locomotor activity it was of interest to determine whether the receptors for somatostin are modulated by the cholinergic nicotine-like effects. An i.v. dose of 0.3 mg/kg nicotine induced an increase in the concentrations of somatostatin-like immunoreactivity at 4 min in the parietal cortex and at 15 min in the hippocampus. These changes were associated with a significant increase in the total number of specific somatostatin receptors in the parietal cortex at 15 min and in the hippocampus at 30 min following injection. To determine if the above mentioned changes are related to the nicotine activation of central nicotine-like acetylcholine receptors, a cholinergic nicotinic blocking agent, mecamylamine, was administered before the nicotine injection. Pretreatment with mecamylamine (5.0 mg/kg i.v.) prevented the nicotine-induced changes in somatostatin level and binding in both brain areas. Mecamylamine alone had no observable effect on the somatostatinergic system. These results suggest that the somatostatinergic system can be regulated by nicotine-like acetylcholine receptors and may be involved in some of the behavioral central effects of nicotine.
PB Elsevier
SN 0014-2999
YR 1990
FD 1990
LK http://hdl.handle.net/10017/2468
UL http://hdl.handle.net/10017/2468
LA eng
NO Comisión Interministerial de Ciencia y Tecnología
DS MINDS@UW
RD 16-abr-2024