RT info:eu-repo/semantics/article
T1 Acute nicotine administration increases somatostatin content and binding in the rat hypothalamus
A1 Barrios Sabador, Vicente
A1 Gonzalez-Parra, S.
A1 Arilla Ferreiro, Eduardo
K1 Nicotine
K1 Somatostatin
K1 Hypothalamus
K1 Bioquímica
K1 Biochemistry
K1 Science
K1 Ciencia
AB Within 4 minutes a single, intravenous injection of nicotine (0.3 mg/Kg) induced increases in somatostatin-like immunoreactivity concentrations in the rat hypothalamus but not in the striatum. These changes were associated with a significant increase in the specific binding of somatostatin to putative receptor sites in hypothalamic membranes, while no significant changes were found in striatum. The enhancement of somatostatin binding resulted from a rapid increase in the number of available receptors rather than a change in receptor affinity. This effect appears to be mediated by nicotinic cholinergic receptors, because pretreatment with a centrally active nicotinic receptor antagonist, mecamylamine (5.0 mg/Kg i.v.), prevented the nicotine-induced changes in somatostatin content and binding in the hypothalamus. Mecamylamine alone had no observable effect on the hypothalamic somatostatinergic system. These results suggest that the rat hypothalamic somatostatinergic system can be regulated by nicotine-like acetylcholine receptors.
PB Pergamon Press
SN 0024-3205
YR 1992
FD 1992
LK http://hdl.handle.net/10017/2439
UL http://hdl.handle.net/10017/2439
LA eng
NO Ministerio de Educación y Ciencia
DS MINDS@UW
RD 24-abr-2024