RT info:eu-repo/semantics/article
T1 One-pot synthesized functionalized mesoporous silica as a reversed-phase sorbent for solid-phase extraction of endocrine disrupting compounds in milks
A1 Gañán, Judith
A1 Morante Zarcero, Sonia
A1 Pérez Quintanilla, Damián
A1 Marina Alegre, María Luisa
A1 Sierra Alonso, Isabel
K1 Solid-phase extraction
K1 SBA-15
K1 Endocrine disrupting compounds estrogens
K1 Milk
K1 Ciencia
K1 Química
K1 Science
K1 Chemistry
AB A new procedure for the determination of 12 naturally occurring hormones and some related synthetic chemicals in milk, commonly used as growth promoters in cattle, is reported. The method is based on liquid–liquid extraction followed by solid-phase extraction (SPE) using a new one-pot synthesized ordered mesoporous silica (of the SBA-15 type) functionalized with octadecyl groups (denoted as SBA-15-C18-CO) as reversed-phase sorbent. The analytes were eluted with methanol and then submitted to HPLC with diode array detection. Under optimal conditions, the method quantification limit for the analytes ranged from 0.023 to 1.36 μg/mL. The sorbent affored the extraction of estrone, 17β-estradiol, estriol, progesterone, hexestrol, diethylstilbestrol, 4-androstene-3,17-dione, ethinylestradiol, 17α-methyltestosterone, nandrolone, prednisolone and testosterone with mean recoveries ranging from 72% to 105% (except for diethylstilbestrol) with RSD < 11%. These results were comparable and, in some cases, even better than those obtained with other extraction methods, therefore SBA-15-C18-CO mesoporous silica possess a high potential as a reversed-phase sorbent for SPE of the 12 mentioned endocrine disrupting compounds in milk samples.
PB Elsevier
SN 0021-9673
YR 2015
FD 2015
LK http://hdl.handle.net/10017/24160
UL http://hdl.handle.net/10017/24160
LA eng
DS MINDS@UW
RD 24-abr-2024