RT info:eu-repo/semantics/article T1 Effects of fasting and refeeding on somatostatin concentration and binding to cytosol from rabbit gastric mucosa A1 Roca, B. A1 Fernández-Valencia Rodríguez, Rafael A1 Arilla Ferreiro, Eduardo K1 Somatostatin K1 Rabbit K1 Stomach K1 Mucosa K1 Bioquímica K1 Biochemistry K1 Science K1 Ciencia AB Somatostatin like immunoreactivity and the density of somatostatin binding sites were measured in stomach (fundus and antrum) from either fed, 12 to 96 hours fasted, or 96 hours fasted plus 48 hours refed rabbits. The somatostatin concentration increased in fundic and antral mucosa after 24 h and reached its highest value after 96 h of fasting. The number of specific somatostatin binding sites with high and low affinity decreased with the duration of fasting. Refeeding of fasted animals resulted in a normalisation to control values of gastric mucosal somatostatin and somatostatin binding. PB Nature Publishing Group SN 0017-5749 YR 1988 FD 1988 LK http://hdl.handle.net/10017/2363 UL http://hdl.handle.net/10017/2363 LA eng NO Instituto de Salud Carlos III DS MINDS@UW RD 18-abr-2024