RT info:eu-repo/semantics/article
T1 Influence of fluoxetine and p-chloroamphetamine on the somatostatin receptor-adenylyl cyclase system in the rat frontoparietal cortex
A1 Muñoz Acedo, Gema
A1 Izquierdo Claros, Rosa María
A1 Puebla Jiménez, Lilian
A1 Rodríguez Martín, Eulalia
A1 Arilla Ferreiro, Eduardo
K1 Fluoxetine
K1 p-Chloroamphetamine
K1 Somatostatin receptor
K1 Adenylyl cyclase
K1 Rat
K1 Frontoparietal cortex
K1 Bioquímica
K1 Biochemistry
K1 Science
K1 Ciencia
AB There is evidence that suggests a reciprocal functional link between the serotonergic and the somatostatinergic system in the rat frontoparietal cortex. However, to date, the role of endogenous 5-hydroxytryptamine (serotonin) on the regulation of the somatostatin (SS) receptor-adenylyl cyclase (AC) system remains unclear. In the present study, the administration of fluoxetine (10 mg/kg i.p.), a 5-hydroxytryptamine uptake inhibitor in a single dose or administered daily for 14 days increased the number of specific [125I]Tyr11-SS receptors, with no change in the receptor affinity, in rat frontoparietal cortical membranes. However, the capacity of SS to inhibit forskolin (FK)-stimulated AC activity in these membranes was lower than in the control groups. The ability of the stable GTP analogue 5'-guanylylimidodiphosphate (Gpp(NH)p) to inhibit FK-stimulated AC activity in frontoparietal cortical membranes was also decreased in rats acutely and chronically treated with fluoxetine. p-Chloroamphetamine (5 mg/kg i.p.), which leads to a lasting reduction of 5-hydroxytryptamine innervation, administered,on days 1, 3 and 5 and the rats sacrificed 1 or 3 weeks after the first injection, decreased the number of SS receptors without changing the receptor affinity. In this experimental group, SS also caused a significantly lower inhibition of FK-stimulated AC activity. p-Chloroamphetamine had no effect on the ability of Gpp(NH)p to inhibit FK-stimulated AC activity in frontoparietal cortical membranes at all the time periods studied. The present results suggest that under normal circumstances some SS receptors are under a tonic stimulatory control through the serotonergic system.
PB Elsevier
SN 0169-328X
YR 1997
FD 1997
LK http://hdl.handle.net/10017/2260
UL http://hdl.handle.net/10017/2260
LA eng
NO Ministerio de Educación y Cultura
DS MINDS@UW
RD 16-abr-2024