RT info:eu-repo/semantics/article
T1 Differential effects of ethanol ingestion on somatostatin content,somatostatin receptors and adenylyl cyclase activity in thefrontoparietal cortex of virgin and parturient rats
A1 Barrios Sabador, Vicente
A1 Puebla Jiménez, Lilian
A1 Boyano Adánez, María del Carmen
A1 Sanz, Manuel
A1 Soriano Guillén, Leandro
A1 Arilla Ferreiro, Eduardo
K1 Ethanol
K1 Somatostatin
K1 Gestation
K1 Frontoparietal cortex
K1 Adenylyl cyclase
K1 Virgin rats
K1 Bioquímica
K1 Biochemistry
K1 Science
K1 Ciencia
AB Chronic ethanol ingestion decreases the number of somatostatin (SRIF) receptors in the rat frontoparietal cortex and female sex hormones modulate the effects of ethanol in the brain. Therefore, we investigated the differential effects of ethanol consumption on the SRIFergic system in the frontoparietal cortex of virgin and parturient rats given ethanol in their drinking water before and during gestation. In parturient rats, ethanol consumption decreased the density of SRIF receptors (25%, p < 0.01 vs control parturient group) whereas the SRIF-like immunoreactivity (SRIF-LI) content was increased (140%, p < 0.01). In virgin rats, ethanol ingestion decreased the density of SRIF receptors (42%, p < 0.01) more than in alcoholic parturient rats. SRIF-LI levels were unaffected. The inhibitory effect of SRIF on basal and forskolin-stimulated adenylyl cyclase was significantly lower in alcoholic virgin rats as compared to alcoholic parturient rats. No differences in the levels of the G inhibitory (Gi) ¿1 and Gi¿2 proteins were observed among the experimental groups. These results suggest that gestation may confer partial resistance to the ethanol-induced effect on the SRIFergic system.
PB Elsevier
SN 0024-3205
YR 2005
FD 2005
LK http://hdl.handle.net/10017/2247
UL http://hdl.handle.net/10017/2247
LA eng
NO Ministerio de Ciencia y Tecnología
DS MINDS@UW
RD 24-abr-2024