RT info:eu-repo/semantics/article
T1 Rapid determination of salbutamol in pharmaceutical preparations by chiral capillary electrophoresis
A1 Ekiert, Ela
A1 García Ruiz, Carmen
A1 García, María A.
A1 Marina Alegre, María Luisa
K1 Chiral capillary electrophoresis
K1 Pharmaceutical preparation
K1 Salbutamol
K1 Ciencia
K1 Química analítica e industrial
K1 Science
K1 Chemistry, analytic and technical
AB A fast and simple method of chiral capillary electrophoresis (CE) has been applied to the analysis of salbutamol in different pharmaceutical preparations. Using of a 25 mM acetate buffer (pH 5.0), containing 13.1 mg/mL carboxymethyl- -cyclodextrin (CM- -CD), an applied voltage of 20 kV and a temperature of 25 C, the enantiomers of salbutamol could be separated in about 2 min. Three different pharmaceutical preparations (two syrups, one oral solution, and two kind of tablets) containing a racemate of salbutamolwere injected directly in the CE system, following dilution in dimethyl sulfoxide(DMSO). Appreciable differences in the retention times were observed for salbutamol enantiomers in the different formulations studied, which were attributed to the effect of the matrix components on the electrophoretic mobility. The standard addition methodwas used for the calibration due to the existence of matrix interferences. Finally, the stability of the enantiomers of salbutamol in the oral solution was studied calculating the enantiomeric ratio values when the solution was injected immediately after being opened in the first case and after being opened and stored in the fridge for two months in the second case.
PB John Wiley & Sons
SN 0173-0835
YR 2003
FD 2003
LK http://hdl.handle.net/10017/1359
UL http://hdl.handle.net/10017/1359
LA eng
NO Comisión Interministerial de Ciencia y Tecnología
DS MINDS@UW
RD 25-abr-2024