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Effects of insulin-induced hypoglycemia on somatostatin level and binding in rat cerebral cortex and hippocampus

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Authors
Rodríguez Sánchez, María Nelly; Colás Escudero, María BegoñaUniversity of Alcalá Author; Prieto Villapún, Juan CarlosUniversity of Alcalá Author; Arilla Ferreiro, EduardoUniversity of Alcalá Author
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/6947
DOI: 10.1016/0006-8993(89)90141-8
ISSN: 0006-8993
Publisher
Elsevier
Date
1989
Affiliation
Universidad de Alcalá. Departamento de Bioquímica y Biología Molecular
Bibliographic citation
Brain Research, 1989, v. 494, n. 1, p. 36-41
Keywords
Insulin-induced hypoglycemia
Somatostatin
Cerebral cortex
Hippocampus
Rat
Project
PB 87-0753 (Comisión Interministerial de Ciencia y Tecnología-CICYT)
88/0903 (Fondo de Investigaciones Sanitarias-FIS)
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/0006-8993(89)90141-8
Rights
© Elsevier Science Publishers, 1989
Access rights
info:eu-repo/semantics/openAccess
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Abstract
The effects of severe insulin-induced hypoglycemia on somatostatin level and specific binding in the cerebral cortex and hippocampus were examined using 125I-Tyr11-somatostatin as a ligand. Severe insulin-induced hypoglycemia did not affect the level of somatostatin-like immunoreactivity in the brain areas studied. However, the number (but not the affinity) of specific somatostatin receptors was significantly decreased in membrane preparation from the hippocampus but not in the cerebral cortex at the onset of hypoglycemia coma (5-10 min). Administration of glucose at the onset of hypoglycemic coma brought about extensive recovery of hippocampal somatostatin receptor number. These results suggest that glucose modulates the somatostatin receptor in the rat hippocampus. The physiological significance of these findings remains to be clarified.
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