Hepatitis E virus seroprevalence is associated with neurodegenerative disorders in older people with dementia: a case-control study
Authors
Pérez García, Felipe; Vázquez Morón, Sonia; Burgueño García, Iván; Muñoz Gómez, María José; Zea Sevilla, María Ascensión; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/60929DOI: 10.1093/infdis/jiac268
ISSN: 0022-1899
Date
2023-04-01Embargo end date
2024-04-01Funders
Centro de Investigación Biomédica en Red en Enfermedades Infecciosas
Agencia Estatal de Investigación
Bibliographic citation
Journal of Infectious Diseases, 2023, v. 227, n. 7, p. 873-877
Keywords
Hepatitis E virus
Seroprevalence
Alzheimer
Vascular pathology
Neurodegenerative disorders
Older people
Description / Notes
5 p.
Project
info:eu-repo/grantAgreement/CIBER//CB21%13%00044/ES//
info:eu-repo/grantAgreement/AEI//PID2019-110401RB-100/ES//
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/acceptedVersion
Rights
© The Author(s) 2022
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
In this case-control study, we evaluated the association between serum antibodies against hepatitis E virus (HEV) and central nervous system (CNS) neurodegenerative disorders (NDs) in older people with dementia. The presence of anti-HEV antibodies was related to a higher adjusted odds ratio (aOR) of having CNS NDs by neuropathological diagnosis (aOR, 2.13; P = .007) and clinical/neuropathological diagnosis (1.84; P = .02). Besides, serum anti-HEV antibodies were directly related to neuropathological injury (higher vascular pathology [aOR, 1.97; P = .006]) and higher probability of Alzheimer-type pathology (1.84; P = .02). In conclusion, the presence of anti-HEV antibodies was related to higher odds of CNS NDs and neuropathological injury in older people.
Files in this item
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hepatitis_perez_JINFECTDIS_2023.pdf | 633.0Kb |
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hepatitis_perez_JINFECTDIS_2023.pdf | 633.0Kb |
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