Differential study of retinal thicknesses in the eyes of Alzheimer's patients, multiple sclerosis patients and healthy subjects
Authors
Garcia-Martín, E.; Jimeno Huete, Daniel; Dongil Moreno, Francisco Javier; Boquete Vázquez, Luciano; Sánchez Morla, Eva María; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/60354DOI: 10.3390/biomedicines11123126
ISSN: 2227-9059
Publisher
MDPI
Date
2023-11-24Funders
Instituto de Salud Carlos III
Universidad de Alcalá
Bibliographic citation
Garcia-Martin, E.; Jimeno-Huete, D.; Dongil-Moreno, F.J.; Boquete, L.; Sánchez-Morla, E.M.; Miguel-Jiménez, J.M.; López-Dorado, A.; Vilades, E.; Fuertes, M.I.; Pueyo, A.; et al. Differential Study of Retinal Thicknesses in the Eyes of Alzheimer’s Patients, Multiple Sclerosis Patients and Healthy Subjects. Biomedicines 2023, 11, 3126.
Keywords
Multiple sclerosis
Alzheimer’s disease
Optical coherence tomography
Posterior pole
Project
info:eu-repo/grantAgreement/ISCIII//PI17%2F01726
info:eu-repo/grantAgreement/ISCIII//PI18%2F1275
info:eu-repo/grantAgreement/ISCIII//PI20%2F00437
info:eu-repo/grantAgreement/ISCIII//RD21%2F0002%2F0050
info:eu-repo/grantAgreement/UAH//UAH-GP2022-2
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
https://doi.org/10.3390/biomedicines11123126Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
© 2023 The authors
Access rights
info:eu-repo/semantics/openAccess
Abstract
Multiple sclerosis (MS) and Alzheimer"s disease (AD) cause retinal thinning that is detectable
in vivo using optical coherence tomography (OCT). To date, no papers have compared the two diseases
in terms of the structural differences they produce in the retina. The purpose of this study is to analyse
and compare the neuroretinal structure in MS patients, AD patients and healthy subjects using OCT.
Spectral domain OCT was performed on 21 AD patients, 33MS patients and 19 control subjects using
the Posterior Pole protocol. The area under the receiver operating characteristic (AUROC) curve was
used to analyse the differences between the cohorts in nine regions of the retinal nerve fibre layer
(RNFL), ganglion cell layer (GCL), inner plexiform layer (IPL) and outer nuclear layer (ONL). The
main differences between MS and AD are found in the ONL, in practically all the regions analysed
(AUROCFOVEAL = 0.80, AUROCPARAFOVEAL = 0.85, AUROCPERIFOVEAL = 0.80, AUROC_PMB = 0.77,
AUROCPARAMACULAR = 0.85, AUROCINFERO_NASAL = 0.75, AUROCINFERO_TEMPORAL = 0.83),
and in the paramacular zone (AUROCPARAMACULAR = 0.75) and infero-temporal quadrant
(AUROCINFERO_TEMPORAL = 0.80) of the GCL. In conclusion, our findings suggest that OCT data
analysis could facilitate the differential diagnosis of MS and AD.
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