Stereoselective separation of sulfoxaflor by electrokinetic chromatography and applications to stability and ecotoxicological studies
Authors
Jiménez Jiménez, Sara; Amariei, Georgiana; Boltes Espínola, Ana Karina; García González, María Ángeles; Marina Alegre, María LuisaIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/60293DOI: 10.1016/j.chroma.2021.462450
ISSN: 00219673
Date
2021-09-27Affiliation
Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaBibliographic citation
Journal of Chromatography A, 2021, v. 1654, n. 462450, p. 1-9
Keywords
electrokinetic chromatography
chiral separation, sulfoxaflor
ecotoxicity
non-target aquatic organisms
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
© 2021 The Authors.
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
An Electrokinetic Chromatography method was developed for the stereoselective analysis of sulfoxaflor, a novel sulfoximine agrochemical with two chiral centers. A screening with fourteen negatively charged CDs was performed and Succinyl-?-CD (Succ-?-CD) was selected. A 15 mM concentration of this CD in a 100 mM borate buffer (pH 9.0), using an applied voltage of 20 kV and a temperature of 15 ?C made possible the baseline separation of the four stereoisomers of sulfoxaflor in 13.8 min. The evaluation of the linearity, accuracy, precision, LODs and LOQs of the method developed showed its performance to be applied to the analysis of commercial agrochemical formulations, the evaluation of the stability of sulfoxaflor stereoisomers under biotic and abiotic conditions, and to predict, for the first time, sulfoxaflor toxicity (using real concentrations instead of nominal concentrations), on two non-target aquatic organisms, the freshwater plant, Spirodela polyrhiza, and the marine bacterium, Vibrio fischeri
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