Pulmonary vascular proliferation in patients with severe COVID-19: an autopsy study
Authors
Pablo Sánchez, Raúl De; Pérez-Mies , Belén; Gómez-Rojo , María; Carretero-Barrio , Irene; Bardi , Tomasso; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/59530DOI: http://hdl.handle.net/10017/59530
ISSN: 0040-6376
Date
2021-03-03Affiliation
Universidad de Alcalá. Departamento de Medicina y Especialidades Médicas. Unidad docente de MedicinaFunders
Instituto de Salud Carlos III
CIBERONC
Instituto Ramón y Cajal de
Investigación Sanitaria Intramural COVID19
Bibliographic citation
Thorax, 2021, v. Online Ahead Ofprint, n. , p. -
Keywords
ARDS
COVID-19
Histology/cytology
Description / Notes
3 p.
Project
info:eu-repo/grantAgreement/ISCIII/PI19%01331/ES//
info:eu-repo/grantAgreement/CIBERONC/CB16%12/00316/ES//
info:eu-repo/grantAgreement/IRCISICOVID19/2020%0290/ES//
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
© Author(s) (or their employer(s))
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Diffuse alveolar damage and thrombi are the most common lung histopathological lesions reported in patients with severe COVID-19. Although some studies have suggested increased pulmonary angiogenesis, the presence of vascular proliferation in COVID-19 lungs has not been well characterised. Glomeruloid-like microscopic foci and/or coalescent vascular proliferations measuring up to 2 cm were present in the lung of 14 out of 16 autopsied patients. These lesions expressed CD31, CD34 and vascular endothelial cadherin. Platelet-derived growth factor receptor-? immunohistochemistry and dual immunostaining for CD34/smooth muscle actin demonstrated the presence of pericytes. These vascular alterations may contribute to the severe and refractory hypoxaemia that is common in patients with severe COVID-19.
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pulmonary_perez_THORAX_2021.pdf | 1.772Mb |
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