Heterofunctional carbosilane polyphenolic dendrons: new antioxidants platforms
Authors
Sanz del Olmo, Natalia; García , Juan Carlos; Gómez Ramírez, Rafael; Mata de la Mata, Francisco Javier de la; Ortega Lopez, PaulaIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/57716DOI: 10.1039/d1ra08224h
ISSN: 2046-2069
Date
2022-03-24Funders
Ministerio de Economía y Competitividad
Junta de Comunidades de Castilla-La Mancha
Ministerio de Ciencia e Innovación
Bibliographic citation
RSC Advances, 2022, v. 12, n. 17, p. 10280-10288
Project
info:eu-repo/grantAgreement/MINECO/CTQ2017-86224-P/ES//
info:eu-repo/grantAgreement/JCCM//SBPLY%2F17%2F180501%2F000358//
info:eu-repo/grantAgreement/MICINN%2FB2017/BMD-3733/ES/IMMUNOTHERCAN-CM
info:eu-repo/grantAgreement/MICINN/B2017%2FBMD-3703/ES/IMMUNOTHERCAN-CM
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
© The authors
Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Reactive oxygen species (ROS) play a critical role in different human pathophysiological processes. ROS, together with nitrogen reactive species, generated as by-products of cellular metabolism or external factors, affects intracellular redox homeostasis. Redox-active groups found in proteins and other compounds such as polyphenols are involved in maintaining intracellular redox homeostasis. In this work, a new family of heterofunctional first-generation carbosilane dendrons functionalised with different polyphenols at the focal point and dimethylammonium groups at the periphery has been obtained through two synthetic strategies: reductive amination and straightforward amidation reaction. Their antioxidant activity has been evaluated through two spectrophotometric methods: ferric reducing antioxidant power (FRAP) assay and 2,2 '-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay to establish a correlation between the number of hydroxyl groups and the antioxidant activity.
Files in this item
Files | Size | Format |
|
---|---|---|---|
Heterofunctional_Sanz_RSCAdvan ... | 947.5Kb |
|
Files | Size | Format |
|
---|---|---|---|
Heterofunctional_Sanz_RSCAdvan ... | 947.5Kb |
|
Collections
- QUIMINOR - Artículos [238]