Fabrication and in vitro evaluation of chitosan-gelatin based aceclofenac loaded scaffold
Authors
Khan Tareen, Fahad; Ullah Khan, Atif; Farhan Ali Khan, Muhammad; Ullah Shah, Kifayat; Rahdar, Abbas; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/55205DOI: https://doi.org/10.1016/j.ijbiomac.2022.10.118
ISSN: 0141-8130
Date
2022-12-11Affiliation
Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaFunders
Comunidad de Madrid
Bibliographic citation
International Journal of Biological Macromolecules, 2022, v. 224, p. 223-232
Keywords
Bio-scaffold
Chitosan
Gelatin
Project
info:eu-repo/grantAgreement/CAM/Estímulo a la Excelencia para Profesores Universitarios Permanentes/EPU-INV%2F2020%2F012/ES/
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Scaffold development is a nascent field in drug development. The scaffolds mimic the innate microenvironment of the body. The goal of this study was to formulate a biocompatible and biodegradable scaffold, loaded with an analgesic drug, aceclofenac (Ace). The bioscaffold is aimed to have optimum mechanical strength and rheology, with drug released in a sustained manner. It was prepared via chemical cross-linking method: a chitosan (CS) solution was prepared and loaded with Ace; gelatin (GEL) was added and the mixture was cross-linked to get a hydrogel. 20 formulations were prepared to optimize different parameters including the stirring speed, drug injection rate and crosslinker volume. The optimal formulation was selected based on the viscosity, drug solubility, homogeneity, porosity and swelling index. A very high porosity and swelling index were attained. In vitro release data showed sustained drug delivery, with effective release at physiological and slightly acidic pH. SEM analysis revealed a homogeneous microstructure with highly interconnected pores within an extended polymer matrix. FT-IR spectra confirmed the absence of polymer-drug interactions, XRD provided evidences for efficient drug entrapment within the scaffold. Rheological analysis corroborated the scaffold injectability. Mathematical models were applied to in-vitro data, and the best fit was attained with Korsmeyer-Peppas.
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