Novel Carboxymethyl cellulose-based hydrogel with core-shell Fe3O4@SiO2 nanoparticles for quercetin delivery
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/55204DOI: https://doi.org/10.3390/ma15248711
ISSN: 1996-1944
Date
2022-12-07Affiliation
Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaBibliographic citation
Materials, 2022, v. 15, n. 24, p. 8711
Keywords
Carboxymethyl cellulose
Quercetin
Fe3O4 nanoparticles
Core–
Shell nanoparticles
Doubleemulsion system
Project
info:eu-repo/grantAgreement/CAM/Estímulo a la Excelencia para Profesores Universitarios Permanentes/EPU-INV%2F2020%2F012/ES/
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
A nanocomposite composed of carboxymethyl cellulose (CMC) and core–shell nanoparticles of Fe3O4@SiO2 was prepared as a pH-responsive nanocarrier for quercetin (QC) delivery. The
nanoparticles were further entrapped in a water-in-oil-in-water emulsion system for a sustained
release profile. The CMC/Fe3O4@SiO2/QC nanoparticles were characterized using dynamic light
scattering (DLS), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), a field
emission scanning electron microscope (FE-SEM), and a vibrating sample magnetometer (VSM) to
obtain insights into their size, stability, functional groups/chemical bonds, crystalline structure, morphology, and magnetic properties, respectively. The entrapment and loading efficiency were slightly
improved after the incorporation of Fe3O4@SiO2 NPs within the hydrogel network. The dialysis
method was applied for drug release studies. It was found that the amount of QC released increased
with the decrease in pH from 7.4 to 5.4, while the sustained-release pattern was preserved. The A549
cell line was chosen to assess the anticancer activity of the CMC/Fe3O4@SiO2/QC nanoemulsion
and its components for lung cancer treatment via an MTT assay. The L929 cell line was used in the
MTT assay to determine the possible side effects of the nanoemulsion. Moreover, a flow cytometry
test was performed to measure the level of apoptosis and necrosis. Based on the obtained results,
CMC/Fe3O4@SiO2 can be regarded as a novel promising system for cancer therapy
Files in this item
Files | Size | Format |
|
---|---|---|---|
Novel_Eshaghi_Materials_2022.pdf | 4.114Mb |
|
Files | Size | Format |
|
---|---|---|---|
Novel_Eshaghi_Materials_2022.pdf | 4.114Mb |
|
Collections
- QUANING - Artículos [367]