LbL Nano-Assemblies: A Versatile Tool for Biomedical and Healthcare Applications
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/55144DOI: https://doi.org/10.3390/nano12060949
ISSN: 2079-4991
Date
2022-05-25Affiliation
Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaBibliographic citation
Nanomaterials, 2022, v. 12, n. 6, p. 949
Keywords
Layer-by-layer
Polyelectrolyte
Nano-assembly
Electrostatic interactions
Polysaccharides
Proteins
Drug delivery
Tissue engineering
Project
info:eu-repo/grantAgreement/CAM/Estímulo a la Excelencia para Profesores Universitarios Permanentes/EPU-INV%2F2020%2F012/ES/
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Access rights
info:eu-repo/semantics/openAccess
Abstract
Polyelectrolytes (PEs) have been the aim of many research studies over the past years. PE films are prepared by the simple and versatile layer-by-layer (LbL) approach using alternating assemblies of polymer pairs involving a polyanion and a polycation. The adsorption of the alternating PE multiple layers is driven by different forces (i.e., electrostatic interactions, H-bonding, charge transfer interactions, hydrophobic forces, etc.), which enable an accurate control over the physical properties of the film (i.e., thickness at the nanoscale and morphology). These PE nano-assemblies have a wide range of biomedical and healthcare applications, including drug delivery, protein delivery, tissue engineering, wound healing, and so forth. This review provides a concise overview of the most outstanding research on the design and fabrication of PE nanofilms. Their nanostructures, molecular interactions with biomolecules, and applications in the biomedical field are briefly discussed. Finally, the perspectives of further research directions in the development of LbL nano-assemblies for healthcare and medical applications are highlighted.
Files in this item
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LbL_Diez_Nanomaterials_2022.pdf | 3.868Mb |
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LbL_Diez_Nanomaterials_2022.pdf | 3.868Mb |
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