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dc.contributor.authorCeprian, Noemi
dc.contributor.authorGonzález De Pablos, Ignaco
dc.contributor.authorOliva, Carlos
dc.contributor.authorFiguer Rubio, Andrea 
dc.contributor.authorPraga, Manuel
dc.contributor.authorAlique Aguilar, Matilde 
dc.contributor.authorRamírez Chamond, Manuel Rafael 
dc.contributor.authorMorales, Enrique
dc.contributor.authorCarracedo Añón, Julia María 
dc.contributor.authorValera, Gemma
dc.contributor.authorCaro, Jara
dc.contributor.authorYuste, Claudia
dc.contributor.authorSerroukh, Nadia
dc.identifier.bibliographicCitationCeprian, N. et al., 2021. Effect of Kidney Transplantation on Accelerated Immunosenescence and Vascular Changes Induced by Chronic Kidney Disease. Frontiers in medicine, 8, p.705159.en
dc.description.abstractKidney transplantation is the best option for patients with end-stage renal disease. Despite the improvement in cardiovascular burden (leading cause of mortality among patients with chronic kidney disease), cardiovascular adverse outcomes related to the inflammatory process remain a problem. Thus, the aim of the present study was to characterize the immune profile and microvesicles of patients who underwent transplantation. We investigated the lymphocyte phenotype (CD3, CD4, CD8, CD19, and CD56) and monocyte phenotype (CD14, CD16, CD86, and CD54) in peripheral blood, and endothelium-derived microvesicles (annexin V+CD31+CD41&-) in plasma of patients with advanced chronic kidney disease (n = 40), patients with transplantation (n = 40), and healthy subjects (n = 18) recruited from the University Hospital "12 de Octubre" (Madrid, Spain). Patients with kidney transplantation had B-cell lymphopenia, an impairment in co-stimulatory (CD86) and adhesion (CD54) molecules in monocytes, and a reduction in endothelium-derived microvesicles in plasma. The correlations between those parameters explained the modifications in the expression of co-stimulatory and adhesion molecules in monocytes caused by changes in lymphocyte populations, as well as the increase in the levels of endothelial-derived microvesicles in plasma caused by changes in lymphocyte and monocytes populations. Immunosuppressive treatment could directly or indirectly induce those changes. Nevertheless, the particular characteristics of these cells may partly explain the persistence of cardiovascular and renal alterations in patients who underwent transplantation, along with the decrease in arteriosclerotic events compared with advanced chronic kidney disease. In conclusion, the expression of adhesion molecules by monocytes and endothelial-derived microvesicles is related to lymphocyte alterations in patients with kidney transplantation.en
dc.description.sponsorshipInstituto de Salud Carlos IIIes_ES
dc.description.sponsorshipSociedad Española de Nefrologíaes_ES
dc.description.sponsorshipComunidad de Madrides_ES
dc.description.sponsorshipFondo Social Europeoes_ES
dc.rightsAttribution 4.0 International (CC BY 4.0)en
dc.rights© 2021 The Authorsen
dc.subjectChronic kidney diseaseen
dc.subjectRenal transplantationen
dc.titleEffect of Kidney Transplantation on Accelerated Immunosenescence and Vascular Changes Induced by Chronic Kidney Disease.en
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Biología de Sistemases_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII// PI19%2F00240/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/ISCIII// PI20%2F01321/ES/en
dc.relation.projectIDinfo:eu-repo/grantAgreement/Comunidad de Madrid//PEJ-2020-AI%2FBMD-18141/ES/en
dc.identifier.publicationtitleFrontiers in Medicineen

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Attribution 4.0 International (CC BY 4.0)
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