Effect of Kidney Transplantation on Accelerated Immunosenescence and Vascular Changes Induced by Chronic Kidney Disease.
Autores
Ceprían, Noemí; González De Pablos, Ignaco; Oliva, Carlos; Figuer Rubio, Andrea; Praga, Manuel; [et al.]Identificadores
Enlace permanente (URI): http://hdl.handle.net/10017/51279DOI: 10.3389/fmed.2021.705159
ISSN: 2296-858X
Fecha de publicación
2021-09-27Patrocinadores
Instituto de Salud Carlos III
Sociedad Española de Nefrología
Comunidad de Madrid
Fondo Social Europeo
Cita bibliográfica
Ceprian, N. et al., 2021. Effect of Kidney Transplantation on Accelerated Immunosenescence and Vascular Changes Induced by Chronic Kidney Disease. Frontiers in medicine, 8, p.705159.
Palabras clave
Chronic kidney disease
Immunity
Immunosenescence
Microvesicles
Renal transplantation
Proyectos
info:eu-repo/grantAgreement/ISCIII//PI17%2F01029/ES/
info:eu-repo/grantAgreement/ISCIII// PI19%2F00240/ES/
info:eu-repo/grantAgreement/ISCIII// PI20%2F01321/ES/
info:eu-repo/grantAgreement/ISCIII//FI20%2F00018/ES/
info:eu-repo/grantAgreement/Comunidad de Madrid//PEJ-2020-AI%2FBMD-18141/ES/
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Derechos
Attribution 4.0 International (CC BY 4.0)
© 2021 The Authors
Derechos de acceso
info:eu-repo/semantics/openAccess
Resumen
Kidney transplantation is the best option for patients with end-stage renal disease. Despite the improvement in cardiovascular burden (leading cause of mortality among patients with chronic kidney disease), cardiovascular adverse outcomes related to the inflammatory process remain a problem. Thus, the aim of the present study was to characterize the immune profile and microvesicles of patients who underwent transplantation. We investigated the lymphocyte phenotype (CD3, CD4, CD8, CD19, and CD56) and monocyte phenotype (CD14, CD16, CD86, and CD54) in peripheral blood, and endothelium-derived microvesicles (annexin V+CD31+CD41&-) in plasma of patients with advanced chronic kidney disease (n = 40), patients with transplantation (n = 40), and healthy subjects (n = 18) recruited from the University Hospital "12 de Octubre" (Madrid, Spain). Patients with kidney transplantation had B-cell lymphopenia, an impairment in co-stimulatory (CD86) and adhesion (CD54) molecules in monocytes, and a reduction in endothelium-derived microvesicles in plasma. The correlations between those parameters explained the modifications in the expression of co-stimulatory and adhesion molecules in monocytes caused by changes in lymphocyte populations, as well as the increase in the levels of endothelial-derived microvesicles in plasma caused by changes in lymphocyte and monocytes populations. Immunosuppressive treatment could directly or indirectly induce those changes. Nevertheless, the particular characteristics of these cells may partly explain the persistence of cardiovascular and renal alterations in patients who underwent transplantation, along with the decrease in arteriosclerotic events compared with advanced chronic kidney disease. In conclusion, the expression of adhesion molecules by monocytes and endothelial-derived microvesicles is related to lymphocyte alterations in patients with kidney transplantation.
Ficheros en el ítem
Ficheros | Tamaño | Formato |
|
---|---|---|---|
effect_ceprian_FM_2021.pdf | 4.943Mb |
|
Ficheros | Tamaño | Formato |
|
---|---|---|---|
effect_ceprian_FM_2021.pdf | 4.943Mb |
|
Colecciones
- FISIOLOG - Artículos [87]