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Enantioselective Copper-Catalyzed Synthesis of Trifluoromethyl-Cyclopropylboronates

dc.contributor.authorAltarejos Salido, Julia 
dc.contributor.authorSucunza Sáenz, David 
dc.contributor.authorVaquero López, Juan J.
dc.contributor.authorCarreras Pérez Aradros, Javier 
dc.date.accessioned2021-09-06T09:42:34Z
dc.date.issued2021-07-28
dc.identifier.bibliographicCitationOrganic Letters, 2021, v. 23, n. 15, p. 6174-6178en
dc.identifier.issn1523-7060
dc.identifier.urihttp://hdl.handle.net/10017/49328en
dc.description.abstractA copper-catalyzed enantioselective cyclopropanation involving trifluorodiazoethane in the presence of alkenyl boronates has been developed. This transformation enables the preparation of 2-substituted-3-(trifluoromethyl)cyclopropylboronates with high levels of stereocontrol. The products are valuable synthetic intermediates by transformation of the boronate group. This methodology can be applied to the synthesis of novel trifluoromethylated analogues of trans-2-arylcyclopropylamines, which are prevalent motifs in biologically active compounds.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en
dc.rights© 2021 American Chemical Societyen
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subject(Trifluoromethyl)cyclopropylboronatesen
dc.subjectEnantioselective cyclopropanationen
dc.subjectTrifluorodiazoethaneen
dc.subjectAlkenyl boronatesen
dc.subjectCopper catalysisen
dc.subjectTrifluoromethylcyclopropanesen
dc.titleEnantioselective Copper-Catalyzed Synthesis of Trifluoromethyl-Cyclopropylboronatesen
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaQuímicaes_ES
dc.subject.ecienciaChemistryen
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Química Orgánica y Química Inorgánicaes_ES
dc.date.updated2021-09-06T09:41:37Z
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1021/acs.orglett.1c02420en
dc.relation.projectIDPID2019-105007GAI00 (Ministerio de Ciencia e Innovación); CTQ2017-85263-R (MINECO); RD16/0009/0015 (RETIC REDinREN, Instituto de Salud Carlos III); CM/JIN/2019-025 (Comunidad de Madrid y Universidad de Alcalá); CCG19/CC-038 (Universidad de Alcalá)es_ES
dc.date.embargoEndDate2022-07-28
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.identifier.uxxiAR/0000037573en
dc.identifier.publicationtitleOrganic Lettersen
dc.identifier.publicationvolume23
dc.identifier.publicationlastpage6178
dc.identifier.publicationissue15
dc.identifier.publicationfirstpage6174


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