Development of chiral methodologies by Capillary Electrophoresis with ultraviolet and Mass Spectrometry detection for duloxetine analysis in pharmaceutical formulations
Authors
Sánchez López, Elena; Montealegre Dondarza, Cristina; Marina Alegre, María Luisa; Crego Navazo, Antonio LuisIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/49007DOI: 10.1016/j.chroma.2014.07.038
ISSN: 00219673
Date
2014-10-10Affiliation
Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaBibliographic citation
Journal of Chromatography A, 2014, v. 1363, p. 356-362
Keywords
Capillary electrophoresis
Duloxetine
Enantioseparation
Mass spectrometry
Partial filling technique
Project
info:eu-repo/grantAgreement/MINECO//CTQ2013-48740-P/ES/METODOLOGIAS AVANZADAS PARA ANALISIS QUIRAL MEDIANTE TECNICAS MICROSEPARATIVAS. BUSQUEDA DE BIOMARCADORES EN SISTEMAS ENANTIOSELECTIVOS/
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
© Elsevier
Access rights
info:eu-repo/semantics/openAccess
Abstract
Two chiral methodologies were developed by capillary electrophoresis (CE) with UV and mass spectrometry (MS) detection to ensure the quality control of the drug duloxetine, commercialized as a pure enantiomer. Both methods were optimized to achieve a high baseline enantioresolution (Rs > 2) and an acceptable precision (RSD values 0.05). (C) 2014 Elsevier B.V. All rights reserved.
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