Separation of phthalates by cyclodextrin modified micellar electrokinetic chromatography. Quantitation in perfumes.
Authors
Pérez Fernández, Virginia; González, Maria José; García González, María Ángeles; Marina Alegre, María LuisaIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/48256DOI: 10.1016/j.aca.2013.03.072
ISSN: 0003-2670
Date
2013-06-11Affiliation
Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaBibliographic citation
Analytica Chimica Acta, 2013, v. 782, p. 67-74
Keywords
Phthalate
Micellar electrokinetic chromatography
Bile salt
Cyclodextrin
Perfume
Project
info:eu-repo/grantAgreement/CAM//S2009/AGR-1464/ES/METODOLOGÍAS ANALÍTICAS INNOVADORAS PARA EL CONTROL DE LA CALIDAD Y LA SEGURIDAD DE LOS ALIMENTOS
info:eu-repo/grantAgreement/MICINN//CTQ2009-09022//ES/NUEVAS ESTRATEGIAS ANALÍTICAS PARA LA DETERMINACIÓN DE ENANTIOMEROS Y PEPTIDOS BIOACTIVOS POR MICRO/NANO TÉCNICAS
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
© Elsevier
Access rights
info:eu-repo/semantics/openAccess
Abstract
A new CE method has been developed for the simultaneous separation of a group of parent phthalates. Due to the neutral character of these compounds, the addition of several bile salts as surfactants (sodium cholate (SC), sodium deoxycholate (SDC), sodium taurodeoxycholate (STDC), sodium taurocholate (STC)) to the separation buffer was explored showing the high potential of SDC as pseudostationary phase. However, the resolution of all the phthalates was not achieved when employing only this bile salt as additive, being necessary the addition of neutral cyclodextrins (CD) and organic modifiers to the separation media. The optimized cyclodextrin modified micellar electrokinetic chromatography (CD-MEKC) method consisted of the employ of a background electrolyte (BGE) containing 25 mM beta-CD-100 mM SDC in a 100 mM borate buffer (pH 8.5) with a 10% (v/v) of acetonitrile, employing a voltage of 30 kV and a temperature of 25 degrees C. This separation medium enabled the total resolution of eight compounds and the partial resolution of two of the analytes, di-n-octyl phthalate (DNOP) and diethyl hexyl phthalate (DEHP) (Rs similar to 0.8), in only 12 min. The analytical characteristics of the developed method were studied showing their suitability for the determination of these compounds in commercial perfumes. In all the analyzed perfumes the most common phthalate was diethyl phthalate (DEP) that appeared in ten of the fifteen analyzed products. Also dimethyl phthalate (DMP), diallyl phthalate (DAP), dicyclohexyl phthalate (DCP), and di-n-pentyl phthalate (DNPP) were found in some of the analyzed samples. (C) 2013 Elsevier B.V. All rights reserved.
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