Recent advances on the use of cyclodextrins in the chiral analysis of drugs by capillary electrophoresis
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/48209DOI: 10.1016/j.chroma.2016.08.029
ISSN: 00219673
Date
2016-10Affiliation
Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaBibliographic citation
Journal of Chromatography A, 2016, v. 1467, p. 79-94
Keywords
Chiral
Capillary electrophoresis
Cyclodextrins
Drugs
Analysis
Enantiomer
Project
info:eu-repo/grantAgreement/MINECO//CTQ2013-48740-P/ES/METODOLOGIAS AVANZADAS PARA ANALISIS QUIRAL MEDIANTE TECNICAS MICROSEPARATIVAS. BUSQUEDA DE BIOMARCADORES EN SISTEMAS ENANTIOSELECTIVOS/
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)
© Elsevier
Access rights
info:eu-repo/semantics/openAccess
Abstract
The most recent advances on the use of cyclodextrins as chiral selectors in capillary electrophoresis for the enantioseparation of drugs are reviewed in this article. The types of cyclodextrins employed and the resolutions achieved are discussed. The use of dual chiral systems, modified capillaries, non-aqueous media or microfluidic devices is also included and the mechanisms for enantioseparation of drugs and the inversion of the enantiomer migration order are studied. The most relevant applications developed to carry out the quantitation of chiral drugs, to assess the enantiomeric purity of pharmaceutical formulations, to study their metabolism or to achieve criminalistic or forensic investigations are described. Article's published in the last six years (period from 2010 to 2015) are considered. (C) 2016 Elsevier B.V. All rights reserved.
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Recent_Saz_JChromA_2016.pdf | 1.381Mb |
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