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dc.contributor.authorOrtega Núñez, Miguel Ángel 
dc.contributor.authorGuzman Merino, Alberto
dc.contributor.authorFraile Martínez, Óscar 
dc.contributor.authorRecio Ruiz, Judith 
dc.contributor.authorPekarek, Leonel 
dc.contributor.authorGonzález Guijarro, Luis A.
dc.contributor.authorGarcía Honduvilla, Natalio Antonio 
dc.contributor.authorÁlvarez de Mon Soto, Melchor 
dc.contributor.authorBuján Varela, María Julia Araceli 
dc.contributor.authorGarcía Gallego, Sandra 
dc.date.accessioned2021-03-08T10:12:56Z
dc.date.available2021-03-08T10:12:56Z
dc.date.issued2020-09-03
dc.identifier.bibliographicCitationPharmaceutics, 2020, v. 12, n. 9 - 874en
dc.identifier.issn1999-4923
dc.identifier.urihttp://hdl.handle.net/10017/46749en
dc.description.abstractInfectious diseases are one of the main global public health risks, predominantly caused by viruses, bacteria, fungi, and parasites. The control of infections is founded on three main pillars: prevention, treatment, and diagnosis. However, the appearance of microbial resistance has challenged traditional strategies and demands new approaches. Dendrimers are a type of polymeric nanoparticles whose nanometric size, multivalency, biocompatibility, and structural perfection offer boundlesspossibilities in multiple biomedical applications. This review provides the reader a general overview about the uses of dendrimers and dendritic materials in the treatment, prevention, and diagnosis of highly prevalent infectious diseases, and their advantages compared to traditional approaches. Examples of dendrimers as antimicrobial agents per se, as nanocarriers of antimicrobial drugs, as well as their uses in gene transfection, in vaccines or as contrast agents in imaging assays are presented.Despite the need to address some challenges in order to be used in the clinic, dendritic materials appear as an innovative tool with a brilliant future ahead in the clinical management of infectiousdiseases and many other health issues.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en
dc.rightsMDPI, 2020en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectdendrimeren
dc.subjectnanoparticleen
dc.subjectinfectionen
dc.subjectbacteriaen
dc.subjectvirusen
dc.subjectfungien
dc.subjectparasiteen
dc.subjectamoebaen
dc.subjectprionen
dc.titleDendrimers and dendritic materials: From laboratory to medical practice in infectious diseasesen
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaChemistryen
dc.subject.ecienciaQuímicaes_ES
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Medicina y Especialidades Médicases_ES
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Biología de Sistemases_ES
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Química Orgánica y Química Inorgánicaes_ES
dc.date.updated2021-03-08T08:15:30Z
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.3390/pharmaceutics12090874en
dc.relation.projectID2017-T2/IND-5243 (Comunidad de Madrid); project NATURDEN CM-JIN-2019-001(Comunidad de Madrid); project DENDROGEL SBPLY-19-180501-000269 (Junta de Comunidades de Castilla-la Mancha).en
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.identifier.uxxiAR/0000035006en
dc.identifier.publicationtitlePharmaceuticsen
dc.identifier.publicationvolume12
dc.identifier.publicationissue9 - 874


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