dc.contributor.author | Ortega Núñez, Miguel Ángel | |
dc.contributor.author | Sáez García, Miguel Ángel | |
dc.contributor.author | Sáinz González, Felipe | |
dc.contributor.author | Fraile Martínez, Óscar | |
dc.contributor.author | García Gallego, Sandra | |
dc.contributor.author | Pekarek, Leonel | |
dc.contributor.author | Bravo Arribas, Coral | |
dc.contributor.author | Coca Menchero, Santiago | |
dc.contributor.author | Álvarez de Mon Soto, Melchor | |
dc.contributor.author | García Honduvilla, Natalio Antonio | |
dc.contributor.author | Asúnsolo del Barco, Ángel | |
dc.date.accessioned | 2021-03-08T10:41:07Z | |
dc.date.available | 2021-03-08T10:41:07Z | |
dc.date.issued | 2020-09-30 | |
dc.identifier.bibliographicCitation | International Journal of Medical Sciences, 2020, v. 17, n. 17, p. 2790-2798 | en |
dc.identifier.issn | 1449-1907 | |
dc.identifier.uri | http://hdl.handle.net/10017/46730 | en |
dc.description.abstract | Background: Chronic venous disease (CVD) is a prevalent lower limb venous pathology that especially affects women, who also show an increased risk of this disease during pregnancy. Studies have shown significant structural changes in the placentas of women with CVD and several markers of tissue damage have been also described. Patients and Methods: To try to understand the different placental pathologies, research efforts have focused on examining metabolomic profiles as indicators of the repercussions of these vascular disorders. This study examines changes produced in the metabolomic profiles of chorionic villi in the placentas of women with CVD. In a study population of 12 pregnant women, 6 with and 6 without CVD, we compared through mass spectroscopy coupled to ultra-high performance liquid chromatography (UHPLC-MS), 240 metabolites in chorionic villus samples. Results: This study is the first to detect in the placental villi of pregnant women with CVD, modifications in lysophosphatidylcholines and amino acids along with diminished levels of other lipids such as triglycerides, sphingomyelins, and non-esterified omega 9 fatty acids, suggesting a role of these abnormalities in the pathogenesis of CVD. Conclusions: Our findings are a starting point for future studies designed to examine the impacts of CVD on maternal and fetal well-being | en |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) | en |
dc.rights | Ortega et al, 2020 | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.subject | chronic venous disease | en |
dc.subject | pregnancy | en |
dc.subject | chorionic villi | en |
dc.subject | triglycerides | en |
dc.subject | sphingomyelins or non-esterified omega 9 fatty acids | en |
dc.title | Lipidomic profiling of chorionic villi in the placentas of women with chronic venous disease | en |
dc.type | info:eu-repo/semantics/article | en |
dc.subject.eciencia | Química | es_ES |
dc.subject.eciencia | Chemistry | en |
dc.contributor.affiliation | Universidad de Alcalá. Departamento de Cirugía, Ciencias Médicas y Sociales | es_ES |
dc.contributor.affiliation | Universidad de Alcalá. Departamento de Medicina y Especialidades Médicas | es_ES |
dc.contributor.affiliation | Universidad de Alcalá. Departamento de Química Orgánica y Química Inorgánica | es_ES |
dc.date.updated | 2021-03-08T10:40:25Z | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.7150/ijms.49236 | en |
dc.relation.projectID | FIS-PI18/00912 (Instituto de Salud Carlos III, Plan Estatal de I+D+i
2013-2016 and the European Development Regional Fund 'A way to achieve
Europe” (ERDF) and B2017/BMD-3804 MITIC-CM (Comunidad de Madrid) | en |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.identifier.uxxi | AR/0000035010 | en |
dc.identifier.publicationtitle | International Journal of Medical Sciences | en |
dc.identifier.publicationvolume | 17 | |
dc.identifier.publicationlastpage | 2798 | |
dc.identifier.publicationissue | 17 | |
dc.identifier.publicationfirstpage | 2790 | |