Show simple item record

dc.contributor.authorD'Elia, Valentina 
dc.contributor.authorRubio Retama, Benito Jorge
dc.contributor.authorOrtega Ojeda, Fernando Ernesto
dc.contributor.authorGarcía Ruiz, Carmen 
dc.contributor.authorMontalvo García, Gemma 
dc.date.accessioned2021-02-24T07:42:40Z
dc.date.available2021-02-24T07:42:40Z
dc.date.issued2018-11-20
dc.identifier.bibliographicCitationColloids and Surfaces A: Physicochemical and Engineering Aspects, 2018, v. 557, p. 43-50en
dc.identifier.issn0927-7757
dc.identifier.urihttp://hdl.handle.net/10017/46567en
dc.description.abstractThis work shows the capability of surface-enhanced Raman spectroscopy (SERS) to detect ultratraces of cocaine(COC) in oral fluid (OF). It proposes a new solid substrate made of gold nanorods (Au NRs) to perform sensitiveanalyses of this complex matrix without any sample pretreatment. The Au NRs were synthetized optimizing thesynthesis conditions, and then characterized and tested as SERS substrate. The presented results demonstratedthat the SERS methodology was able to detect COC in OF with a limit of detection (LOD) as low as 10 ng/mL.This value was five orders of magnitude smaller than the one obtained with Raman spectroscopy (RS) and in theorder of the cut-off value (8 ng/mL) established for confirmatory test of COC in OF. Besides, a multivariateanalysis (OPLS-DA) applied on the samples analysed by SERS evidenced that it was possible to discriminateamong various COC concentrations. These are quite positive results because even the 1 ng/mL COC concentration sample could be identified as different from the OF sample. In addition, the absence of samplepretreatment and the ease of the proposed method, allowed performing rapid and non-destructive analyses,making the method suitable for in situ forensic analyses.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en
dc.rights© Elsevier, 2018en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/en
dc.subjectCocaineen
dc.subjectnanoparticlesen
dc.subjectgold nanorodsen
dc.subjectoral fluiden
dc.subjectsurface enhanced Raman spectroscopyen
dc.subjectorthogonal partial least squares to latent structures-discriminate analysis (OPLS-DA)en
dc.titleGold nanorods as SERS substrate for the ultratrace detection of cocaine in non-pretreated oral fluid samplesen
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaQuímicaes_ES
dc.subject.ecienciaChemistryen
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería Químicaes_ES
dc.date.updated2021-02-24T07:42:06Z
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1016/j.colsurfa.2018.05.068en
dc.relation.projectIDCCG2015/EXP-028 (Universidad de Alcalá)es_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.identifier.uxxiAR/0000029384en
dc.identifier.publicationtitleColloids and Surfaces A: Physicochemical and Engineering Aspectsen
dc.identifier.publicationvolume557
dc.identifier.publicationlastpage50
dc.identifier.publicationfirstpage43


Files in this item

Thumbnail

This item appears in the following Collection(s)

Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
Este ítem está sujeto a una licencia Creative Commons.