Potential of high-resolution mass spectrometry for the detection of drugs and metabolites in hair: methoxetamine in a real forensic case
Authors
Montalvo García, Gemma; García Ruiz, Carmen; Matey Cabañas, Jose Manuel; López Fernández, Adrián; Moreno De Simon, M. D.; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/45567DOI: 10.1093/jat/bkaa168
ISSN: 0146-4760
Date
2020-10-26Embargo end date
2021-10-26Affiliation
Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaBibliographic citation
Journal of Analytical Toxicology, 2020, p. 1-10
Project
IUICP-2019/07 (Instituto Universitario de Investigación en Ciencias Policiales, Universidad de Alcalá)
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
© Oxford University Press
Access rights
info:eu-repo/semantics/openAccess
Abstract
The analysis of drugs of abuse in hair and other biological matrices of forensic interest requires great selectivity and sensitivity. This is done traditionally through target analysis, with one or more analytical methods, or with different and specific preanalytical phases, and complex procedures performed by the toxicological laboratories, and there is no exception with ketamine-like compounds, such as methoxetamine, a new psychoactive substance whose use has increased in the last decades, and continues to grow quickly year by year. More validated methods of analysis are needed to detect these substances in low concentrations selectively. Reanalyzing the samples of a former case of a polydrug consumer accused of a crime against public health in Spain, five metabolites of methoxetamine (normethoxetamine, O-desmethylmethoxetamine, dehydromethoxetamine, dihydronormethoxetamine and hydroxynormethoxetamine) were tentatively detected using a high-resolution technique, i.e., liquid chromatography coupled to high-resolution mass spectrometry (LC&-HR-MS-MS). The highest analytical selectivity of LC&-HR-MS-MS method together a universal and simpler pretreatment stages has demonstrated to allow faster analysis and more sensitivity than the one performed traditionally at the INTCF laboratories, which was gas chromatography coupled to mass spectrometry.
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