Multiple protective effect of peptides released from Olea Europaea and Prunus Persica seeds against oxidative damage and cancer cell proliferation
Identificadores
Enlace permanente (URI): http://hdl.handle.net/10017/44487DOI: 10.1016/j.foodres.2018.01.015
ISSN: 0963-9969
Fecha de publicación
2018-04Filiación
Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería QuímicaCita bibliográfica
Food Research International, 2018, v. 106, p. 458-467
Palabras clave
Peptides
Seed
Olive
Prunus
Oxidative damage
Cell proliferation
Mass spectrometry
Proyectos
info:eu-repo/grantAgreement/CAM//S2013%2FABI-3028/ES/Estrategias avanzadas para la mejora y el control de la calidad y la seguridad de los alimentos/AVANSECAL-CM
info:eu-repo/grantAgreement/MINECO//AGL2016-79010-R/ES/DESARROLLO DE METODOS SOSTENIBLES PARA EL APROVECHAMIENTO DE SUBPRODUCTOS DE LA INDUSTRIA ALIMENTARIA CON ELEVADO CONTENIDO PROTEICO
info:eu-repo/grantAgreement/CDTI//ITC-20151193/ES/DESARROLLO DE NUEVOS ALIMENTOS FUNCIONALES BASADOS EN LA INCORPORACIÓN DE PÉPTIDOS BIOACTIVOS EXTRAÍDOS A PARTIR DE SUBPRODUCTOS DE LA INDUSTRIA AGROALIMENTARIA: VALORIZACIÓN DE HUESOS DE FRUTAS Y ACEITUNAS
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Derechos
Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)
© Elsevier
Derechos de acceso
info:eu-repo/semantics/openAccess
Resumen
The long exposition to reactive species results in oxidative stress which has been related with the development of cancer and other serious diseases. Olea europaea and Prunus persica seeds present a high protein content and preliminary results demonstrated their high potency to obtain bioactive peptides. The protective effect against oxidative damage exerted by peptides released from Olea europaea and Prunus persica seeds has been evaluated in this work. Seed hydrolysates showed protection against oxidation through four different mechanisms: inhibition of the formation of hydroxyl radicals, scavenging of free radicals, reduction of oxidizing compounds, and inhibition of lipid peroxidation. Moreover, seed hydrolysates also reduced the oxidative stress induced by an oxidizing agent on human cancer cells. Despite protection evaluated by individual mechanisms seemed to be significantly affected by the seed genotype, overall protection of seed hydrolysates was not so different. Seeds hydrolysates were not cytotoxic on normal cells but they demonstrated antiproliferative effect on human cancer cells (HeLa, PC-3, and HT-29). Peptides in all seed hydrolysates were sequenced by RP-HPLC-ESI-Q-TOF. Eighteen common peptides were observed among olive seed hydrolysates while a wider variability was observed among Prunus seed hydrolysates.
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