Optimized synthesis of di, tri and tetrafused pyridazinium cations

Authors
Siro Herrero, Jorge G.; Ramos González, AndrésUniversity of Alcalá Author; Vaquero López, Juan J.; Álvarez-Builla Gómez, JulioUniversity of Alcalá Author; García Navío, José LuisUniversity of Alcalá Author
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/4192
DOI: 10.1016/S0040-4020(00)00079-X
ISSN: 0040-4020
Publisher
Elsevier
Date
2000
Affiliation
Universidad de Alcalá. Departamento de Química Orgánica
Funders
Ministerio de Educación y Ciencia
Universidad de Alcalá
Bibliographic citation
Tetrahedron, 2000, v.56, n.16, p.2469-2472
Keywords
Westphal
Condensations
Polycyclic heterocyclic ions
Computer-assisted methods
Project
SAF 98-0093 (Comision Interministerial de Ciencia y Tecnologia-CICYT)
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/S0040-4020(00)00079-X
Rights
© Elsevier, 2000
Access rights
info:eu-repo/semantics/openAccess
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Abstract
By combining two complementary statistical techniques (fractional factorial experimental design and simplex operation) the synthesis of the parent pyrido[1,2-b]-pyridazinium cation has been successfully carried out (the yield was improved from less than 10 to 65%) by basic condensation of 2-methyl-1-aminopyridinium mesitylenesulfonate and [1,4]dioxane-2,3-diol. Using the optimized reaction conditions, other related heterocyclic cations could be prepared, and two interesting examples are now reported.
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