Optimized synthesis of di, tri and tetrafused pyridazinium cations

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Authors
Siro Herrero, Jorge G.; Ramos González, AndrésUniversity of Alcalá Author; Vaquero López, Juan JoséUniversity of Alcalá Author; Álvarez-Builla Gómez, JulioUniversity of Alcalá Author; García Navío, José LuisUniversity of Alcalá Author
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/4192
DOI: 10.1016/S0040-4020(00)00079-X
ISSN: 0040-4020
Publisher
Elsevier
Date
2000
Academic Departments
Universidad de Alcalá. Departamento de Química Orgánica
Teaching unit
Unidad docente Química Orgánica
Funders
Ministerio de Educación y Ciencia
Comisión Asesora de Investigación Científica y Técnica
Bibliographic citation
Tetrahedron, 2000, v.56, n.16, p.2469-2472
Keywords
Westphal
Condensations
Polycyclic heterocyclic ions
Computer-assisted methods
Project
info:eu-repo/grantAgreement/CAICYT//SAF98-0093/ES/Nuevos agentes citotóxicos basados en cationes de quinolizinio y azaquinolizinio. diseño, síntesis y caracterización de su interacción con ADN
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/S0040-4020(00)00079-X
Rights
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Access rights
info:eu-repo/semantics/openAccess
Abstract
By combining two complementary statistical techniques (fractional factorial experimental design and simplex operation) the synthesis of the parent pyrido[1,2-b]-pyridazinium cation has been successfully carried out (the yield was improved from less than 10 to 65%) by basic condensation of 2-methyl-1-aminopyridinium mesitylenesulfonate and [1,4]dioxane-2,3-diol. Using the optimized reaction conditions, other related heterocyclic cations could be prepared, and two interesting examples are now reported.

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