Azonia derivatives of the γ-carboline system. A new class of DNA intercalators

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Authors
Molina Ponce, AndrésUniversity of Alcalá Author; Vaquero López, Juan JoséUniversity of Alcalá Author; García Navío, José LuisUniversity of Alcalá Author; Álvarez-Builla Gómez, JulioUniversity of Alcalá Author; Rodrigo López, María MeliaUniversity of Alcalá Author; [et al.]
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/4176
DOI: 10.1016/S0960-894X(96)00243-0
ISSN: 0960-894X
Publisher
Elsevier
Date
1996
Academic Departments
Universidad de Alcalá. Departamento de Química Orgánica
Teaching unit
Unidad docente Química Orgánica
Funders
Instituto de Qulmica Computacional
Comisión Interministerial de Ciencia y Tecnología
Bibliographic citation
Bioorganic & Medicinal Chemistry Letters, 1996, v.6, n.13, p.1453-1456
Keywords
DNA intercalators
Azonia derivatives
γ-carboline system
Project
info:eu-repo/grantAgreement/ICYT//SAF94-0280/ES/Nuevos agentes bisintercalantes selectivos sobre AON
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/S0960-894X(96)00243-0
Rights
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
Access rights
info:eu-repo/semantics/openAccess
Abstract
1-Methyl-γ-carboline derivatives were transformed into the corresponding N-aminoazinium salts, which were condensed with 1,2-dicarbonyl compounds (Westphal reaction) to afford azonia derivatives with a bridgehead quaternary nitrogen atom. Some of them show DNA intercalating properties.

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