dc.contributor.author | Xu, Dongsheng | |
dc.contributor.author | Shao, Huikai | |
dc.contributor.author | Luo, Rongying | |
dc.contributor.author | Wang, Qiqin | |
dc.contributor.author | Sánchez López, Elena | |
dc.contributor.author | Fanali, Salvatore | |
dc.contributor.author | Marina Alegre, María Luisa | |
dc.contributor.author | Jiang, Z. | |
dc.date.accessioned | 2020-03-09T07:32:37Z | |
dc.date.available | 2020-03-09T07:32:37Z | |
dc.date.issued | 2018-07-06 | |
dc.identifier.bibliographicCitation | Journal of Chromatography A. 2018, v. 1557, p. 43-50 | en |
dc.identifier.issn | 0021-9673 | |
dc.identifier.uri | http://hdl.handle.net/10017/41506 | en |
dc.description.abstract | A facile single-step preparation strategy for fabricating vancomycin functionalized organic polymer based monolith within 100 mu m fused-silica capillary was developed. The synthetic chiral functional monomer, i.e 2-isocyanatoethyl methacrylate (ICNEML) derivative of vancomycin, was co-polymerized with the cross-linker ethylene dimethacrylate (EDMA) in the presence of methanol and dimethyl sulfoxide as the selected porogens. The co-polymerization conditions were systematically optimized in order to obtain satisfactory column performance. Adequate permeability, stability and column morphology were observed for the optimized poly(ICNEML-vancomycin-co-EDMA) monolith. A series of chiral drugs were evaluated on the monolith in either several other beta-blockers. The proposed single-step approach not only resulted in a vancomycin functionalized organer polar organic-phase or reversed-phase modes. After the optimization of separation conditions, baseline or partial enantioseparation were obtained for series of drugs including thalidomide, colchicine, carteolol, salbutamol, clenbuterol andic polymer-based monolith with acceptable performance, but also significantly simplified the preparation procedure by reducing time and labor. | en |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) | en |
dc.rights | © Elsevier | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | en |
dc.subject | Vancomycin | en |
dc.subject | Enantioseparation | en |
dc.subject | Organic polymeric monolith | en |
dc.subject | Nano-LC | en |
dc.title | A facile and efficient single-step approach for the fabrication of vancomycin functionalized polymer-based monolith as chiral stationary phase for nano-liquid chromatography | en |
dc.type | info:eu-repo/semantics/article | en |
dc.subject.eciencia | Química | es_ES |
dc.subject.eciencia | Chemistry | en |
dc.contributor.affiliation | Universidad de Alcalá. Departamento de Química Analítica, Química Física e Ingeniería Química | |
dc.date.updated | 2020-03-09T07:31:32Z | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.1016/j.chroma.2018.05.004 | en |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.identifier.uxxi | AR/0000028737 | en |
dc.identifier.publicationtitle | Journal of Chromatography A | en |
dc.identifier.publicationvolume | 1557 | |
dc.identifier.publicationlastpage | 50 | |
dc.identifier.publicationfirstpage | 43 | |