High-performance liquid-chromatographic determination of the pi-values of azol-N-yl substituents

Authors
Álvarez-Builla Gómez, JulioUniversity of Alcalá Author; Crespo, Teresa; López, Raquel; Elguero, José; Toiron, Catherine; [et al.]
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/3920
DOI: 10.1002/jps.2600810623
ISSN: 0022-3549
Publisher
American Pharmacists Association
Wiley
Date
1992
Affiliation
Universidad de Alcalá. Departamento de Química Orgánica
Funders
J. A. B., T. C., and R.L.acknowledge financial support from the Comisión lnterministerial de Ciencia y Tecnología through project. PB87-0755.
Bibliographic citation
Journal of Pharmaceutical Sciences, 1992 v. 81, n. 6, p. 577-580
Keywords
Hydrophobicity measurements
Partition-coefficients
Behavior
Water
Project
PB87-0755 (Comisión Interministerial de Ciencia y Tecnología-CICYT)
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1002/jps.2600810623
Rights
(c) American Pharmaceutical Association, 1992
Access rights
info:eu-repo/semantics/openAccess
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Abstract
The π (hydrophobic constant) values for 16 parent azoles (pyrrole, imidazole, pyrazole, four triazoles, two tetrazoles, indole, benzimidazole, 1 H and 2H-indazoles, 1H-and 2H-benzotriazoles, and carbazole) were calculated from the logarithms of the capacity factors (log k′) determined by HPLC. The values thus obtained are discussed according to an additive model in which the number and position of pyridinelike nitrogen atoms and the annelation effect are considered.
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