Synthesis and structure of new pyrido[2,3-D]pyrimidine derivatives with calcium-channel antagonist activity

Author
Pastor del Castillo, AlfredoUniversity of Alcalá Author; Alajarín Ferrández, RamónUniversity of Alcalá Author; Vaquero López, Juan J.University of Alcalá Author; Álvarez-Builla Gómez, JulioUniversity of Alcalá Author; Casa-Juana Muñoz, Miguel Fau de; [et al.]
Identifiers
Enlace permanente (URI): http://hdl.handle.net/10017/3697
DOI: 10.1016/S0040-4020(01)85291-1
ISSN: 0040-4020
Publisher
Pergamon
Date
1994
Filiación
Universidad de Alcalá. Departamento de Química Orgánica
Patrocinadores
We gratefully acknowledge to ALTER S. A. for studentship (to A. P and R. A.) and financial support
Cita bibliográfica
Tetrahedron, 1994, v. 50, n. 27, p. 8085-8098
Palabras clave
Pyrido[2,3-D]pyrimidine derivatives
Calcium-channel
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Versión del editor
http://dx.doi.org/10.1016/S0040-4020(01)85291-1
Derechos
(c) Elsevier, 1994
Derechos de acceso
info:eu-repo/semantics/openAccess
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Abstract
Several series of pyrido[2,3-d]pyrimidine derivatives were synthesized by reaction of aryl methyleneacetoacetates with different aminopyrimidines. The solid-state structure of the methyl 5-(3'-chlorophenyl)-7-methyl-4-oxo-2-thioxo-1,2,3,4,5,8-hexahydropyrido[ 2,3-d]pyrimidine-6-carboxylate shows that these compounds can adopt some of the most important structural features of the 1,4-dihydropyridine calcium channel blockers. The scope and limitations of the synthetic procedure with different aminoheterocycles is presented together with the initial evaluation of their calcium antagonistic activity by comparison with the usual reference compound nifedipine.
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