Synthesis and structure of new pyrido[2,3-D]pyrimidine derivatives with calcium-channel antagonist activity

Authors
Pastor del Castillo, AlfredoUniversity of Alcalá Author; Alajarín Ferrández, Luis RamónUniversity of Alcalá Author; Vaquero López, Juan J.; Álvarez-Builla Gómez, JulioUniversity of Alcalá Author; Casa-Juana Muñoz, Miguel Fau de; [et al.]
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/3697
DOI: 10.1016/S0040-4020(01)85291-1
ISSN: 0040-4020
Publisher
Pergamon
Date
1994
Affiliation
Universidad de Alcalá. Departamento de Química Orgánica
Funders
We gratefully acknowledge to ALTER S. A. for studentship (to A. P and R. A.) and financial support
Bibliographic citation
Tetrahedron, 1994, v. 50, n. 27, p. 8085-8098
Keywords
Pyrido[2,3-D]pyrimidine derivatives
Calcium-channel
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/S0040-4020(01)85291-1
Rights
(c) Elsevier, 1994
Access rights
info:eu-repo/semantics/openAccess
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Abstract
Several series of pyrido[2,3-d]pyrimidine derivatives were synthesized by reaction of aryl methyleneacetoacetates with different aminopyrimidines. The solid-state structure of the methyl 5-(3'-chlorophenyl)-7-methyl-4-oxo-2-thioxo-1,2,3,4,5,8-hexahydropyrido[ 2,3-d]pyrimidine-6-carboxylate shows that these compounds can adopt some of the most important structural features of the 1,4-dihydropyridine calcium channel blockers. The scope and limitations of the synthetic procedure with different aminoheterocycles is presented together with the initial evaluation of their calcium antagonistic activity by comparison with the usual reference compound nifedipine.
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