Synthesis of L-2-amino-8-oxodecanoic acid: an amino acid component of apicidins

Author
Linares de la Morena, María Lourdes; Agejas Chicharro, Francisco Javier; Alajarín Ferrández, RamónUniversity of Alcalá Author; Vaquero López, Juan J.University of Alcalá Author; Álvarez-Builla Gómez, JulioUniversity of Alcalá Author
Identifiers
Enlace permanente (URI): http://hdl.handle.net/10017/3680
DOI: 10.1055/s-2006-942395
ISSN: 0039-7881
Publisher
Thieme
Date
2001
Filiación
Universidad de Alcalá. Departamento de Química Orgánica
Patrocinadores
Universidad de Alcalá
Fundación General de la Universidad de Alcalá
FEDER
Cita bibliográfica
Synthesis, 2001, n.12, p.2069-2073
Palabras clave
Amino acid
Aoda
Apicidins
Histone deacetylase
Inhibitors
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Versión del editor
http://dx.doi.org/10.1055/s-2006-942395
Derechos
© 2001, Georg Thieme Verlag
Derechos de acceso
info:eu-repo/semantics/openAccess
Share
 
Abstract
The synthesis Of L-2-amino-8-oxodecanoic acid (Aoda) is described. This is a rare amino acid component of apicidins, a family of new cyclic tetrapeptides, inhibitors of histone deacetylase. Aoda was synthesised in seven steps from L-glutamic acid along with some derivatives.
Files in this item
Collections