Synthesis of L-2-amino-8-oxodecanoic acid: an amino acid component of apicidins

Authors
Linares de la Morena, María LourdesUniversity of Alcalá Author; Agejas Chicharro, Francisco JavierUniversity of Alcalá Author; Alajarín Ferrández, Luis RamónUniversity of Alcalá Author; Vaquero López, Juan J.; Álvarez-Builla Gómez, JulioUniversity of Alcalá Author
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/3680
DOI: 10.1055/s-2006-942395
ISSN: 0039-7881
Publisher
Thieme
Date
2001
Affiliation
Universidad de Alcalá. Departamento de Química Orgánica
Funders
Universidad de Alcalá
Fundación General de la Universidad de Alcalá
FEDER
Bibliographic citation
Synthesis, 2001, n.12, p.2069-2073
Keywords
Amino acid
Aoda
Apicidins
Histone deacetylase
Inhibitors
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1055/s-2006-942395
Rights
© 2001, Georg Thieme Verlag
Access rights
info:eu-repo/semantics/openAccess
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Abstract
The synthesis Of L-2-amino-8-oxodecanoic acid (Aoda) is described. This is a rare amino acid component of apicidins, a family of new cyclic tetrapeptides, inhibitors of histone deacetylase. Aoda was synthesised in seven steps from L-glutamic acid along with some derivatives.
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