Synthesis of L-2-amino-8-oxodecanoic acid: an amino acid component of apicidins
Authors
Linares de la Morena, María Lourdes; Agejas Chicharro, Francisco Javier; Alajarín Ferrández, Luis Ramón; Vaquero López, Juan J.; Álvarez-Builla Gómez, JulioIdentifiers
Permanent link (URI): http://hdl.handle.net/10017/3680DOI: 10.1055/s-2006-942395
ISSN: 0039-7881
Publisher
Thieme
Date
2001Funders
Universidad de Alcalá
Fundación General de la Universidad de Alcalá
FEDER
Bibliographic citation
Synthesis, 2001, n.12, p.2069-2073
Keywords
Amino acid
Aoda
Apicidins
Histone deacetylase
Inhibitors
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1055/s-2006-942395Rights
© 2001, Georg Thieme Verlag
Access rights
info:eu-repo/semantics/openAccess
Abstract
The synthesis Of L-2-amino-8-oxodecanoic acid (Aoda) is described. This is a rare amino acid component of apicidins, a family of new cyclic tetrapeptides, inhibitors of histone deacetylase. Aoda was synthesised in seven steps from L-glutamic acid along with some derivatives.
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