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dc.contributor.authorDíaz Martínez, Adolfo 
dc.contributor.authorSiro Herrero, Jorge G.
dc.contributor.authorGarcía Navío, José Luis 
dc.contributor.authorVaquero López, Juan J.
dc.contributor.authorÁlvarez-Builla Gómez, Julio 
dc.date.accessioned2009-07-15T04:50:49Z
dc.date.available2009-07-15T04:50:49Z
dc.date.issued1997
dc.identifier.bibliographicCitationSynthesis, 1997, n. 5, p. 559-562en
dc.identifier.issn0039-7881
dc.identifier.urihttp://hdl.handle.net/10017/3591
dc.description.abstractA stereoselective synthesis of (R)-(-)-rolipram from L-glutamic acid is described. The key step is a stereoselective Michael addition of an arylcuprate to a modified pyroglutamic derivative which acts as the template to induce the stereoselectivity. Facile manipulation of the enantiomerically pure Michael product afforded the expected therapeutic agent.en
dc.description.sponsorshipWe gratefully acknowledge ZAMBON GROUP for studentships (to A. D. and J. S.) and financial support.en
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherVerlagen
dc.rights(c) Wiley, 1997en
dc.subjectGlutamic aciden
dc.subjectRolipramen
dc.subjectArticleen
dc.subjectCentral nervous system diseaseen
dc.subjectChemical modificationen
dc.subjectChiralityen
dc.subjectDrug synthesisen
dc.subjectEnantiomeren
dc.subjectReaction analysisen
dc.subjectStereochemistryen
dc.titleA stereoselective synthesis of (R)-(-)-rolipram from L-glutamic aciden
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaCIENCIAes_ES
dc.subject.ecienciaQuímica orgánicaes_ES
dc.subject.ecienciaSCIENCEen
dc.subject.ecienciaChemistry, organicen
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Química Orgánica
dc.relation.publisherversionhttp://dx.doi.org/10.1002/chin.199741254
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1002/chin.199741254
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen


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