Microvesicles from the plasma of elderly subjects and from senescent endothelial cells promote vascular calcification
Authors
Alique Aguilar, Matilde; Ruiz Torres, María Piedad; Bodega Magro, Guillermo; Noci Luna, Victoria; Troyano Suárez, Nuria; [et al.]Identifiers
Permanent link (URI): http://hdl.handle.net/10017/35846DOI: 10.18632/aging.101191
ISSN: 1945-4589
Date
2017Affiliation
Universidad de Alcalá. Departamento de Fisiología; Universidad de Alcalá. Departamento de Biomedicina y Biotecnología; Universidad de Alcalá. Departamento de Biología de SistemasFunders
Instituto de Salud Carlos III
Fondos Feder European
Red Española de Investigación en Enfermedades Renales
Universidad de Alcalá
Junta de Andalucía
Bibliographic citation
Aging, 2017, v. 9, n. 3, p. 778-789
Keywords
Aging
Senescence
Microvesicles
Vascular calcification
Endothelial cells
Vascular smooth muscle cells
Project
info:eu-repo/grantAgreement/ISCIII//PI15%2F01785/ES/Actividad inflamatoria mediada por la interacción de CD14+CD16+ con endotelio: Un proceso implicado en la inducción de calcificación vascular en pacientes con enfermedad renal crónica
info:eu-repo/grantAgreement/REDinREN//RD16%2F0009%2F0034//ES
info:eu-repo/grantAgreement/Junta de Andalucía//P11-CTS7352/ES/Papel modulador de micropartículas endoteliales en el desarrollo de daño endotelial, arteriosclerosis y calcificación vascular
info:eu-repo/grantAgreement/ISCIII//PI11%2F01536/ES/Senescencia de células endoteliales y generación de micropartículas. Un mecanismo común en la etiopatogenia de la arteriosclerosis del anciano y el enfermo con insuficiencia renal crónica
info:eu-repo/grantAgreement/ISCIII//PI12%2F01489/ES/INFLAMACIÓN Y ENFERMEDAD VASCULAR CALCIFICANTE EN LA UREMIA
info:eu-repo/grantAgreement/ISCIII//PI14%2F00806/ES/PAPEL DE MICRORNAS VEHICULADOS POR MICROPARTÍCULAS DE CÉLULAS SENESCENTES EN LA ENFERMEDAD VASCULAR ASOCIADA A LA ENFERMEDAD RENAL CRÓNICA POR NEFROPATÍA DIABÉTICA
info:eu-repo/grantAgreement/Junta de Andalucía//P010-CTS-6337/ES/Papel de los agentes moduladores de la eritropoyesis en la protección del endotelio vascular frente al daño asociado a la inflamación crónica
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Rights
Attribution 4.0 International (CC BY 4.0)
© 2017 The authors
Access rights
info:eu-repo/semantics/openAccess
Abstract
Vascular calcification is commonly seen in elderly people, though it can also appear in middle-aged subjects affected by premature vascular aging. The aim of this work is to test the involvement of microvesicles (MVs) produced by senescent endothelial cells (EC) and from plasma of elderly people in vascular calcification. The present work shows that MVs produced by senescent cultured ECs, plus those found in the plasma of elderly subjects, promote calcification in vascular smooth muscle cells. Only MVs from senescent ECs, and from elderly subjects' plasma, induced calcification. This ability correlated with these types of MVs' carriage of: a) increased quantities of annexins (which might act as nucleation sites for calcification), b) increased quantities of bonemorphogenic protein, and c) larger Ca contents. The MVs of senescent, cultured ECs, and those present in the plasma of elderly subjects, promote vascular calcification. The present results provide mechanistic insights into the observed increase in vascular calcification-related diseases in the elderly, and in younger patients with premature vascular aging, paving the way towards novel therapeutic strategies.
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