Synthesis and chromatographic-separation of the stereoisomers of furnidipine

Authors
Alajarín Ferrández, Ramón; Álvarez-Builla Gómez, JulioUniversity of Alcalá Author; Vaquero López, Juan J.University of Alcalá Author; Sunkel Letelier, Carlos; Casa-Juana Muñoz, Miguel Fau de; [et al.]
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/3584
DOI: 10.1016/S0957-4166(00)80162-7
ISSN: 0957-4166
Publisher
Pergamon
Date
1993
Affiliation
Universidad de Alcalá. Departamento de Química Orgánica
Bibliographic citation
Tetrahedron: Asymmetry, 1993, v.4, n.4, p.617-620
Keywords
Fumidipine
Synthesis
Chiral HPLC
Four stereoisomers
Separation
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/S0957-4166(00)80162-7
Rights
© Elsevier, 1993
Access rights
info:eu-repo/semantics/openAccess
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Abstract
The four stereoisomers of methyl tetrahydrofuran-2-ylmethyl 2,6-dimethyl-4-(o-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxilate (furnidipine), have been synthesized and separated by chiral chromatography using D-phenylglycine as chiral stationary phase. Enantiomeric purity of stereoisomers is determined by HPLC-CSP technique and configurations deduced via X-ray crystallography.
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