Synthesis and chromatographic-separation of the stereoisomers of furnidipine

Author
Alajarín Ferrández, RamónUniversity of Alcalá Author; Álvarez-Builla Gómez, JulioUniversity of Alcalá Author; Vaquero López, Juan J.University of Alcalá Author; Sunkel Letelier, Carlos; Casa-Juana Muñoz, Miguel Fau de; [et al.]
Identifiers
Enlace permanente (URI): http://hdl.handle.net/10017/3584
DOI: 10.1016/S0957-4166(00)80162-7
ISSN: 0957-4166
Publisher
Pergamon
Date
1993
Filiación
Universidad de Alcalá. Departamento de Química Orgánica
Cita bibliográfica
Tetrahedron: Asymmetry, 1993, v.4, n.4, p.617-620
Palabras clave
Fumidipine
Synthesis
Chiral HPLC
Four stereoisomers
Separation
Tipo de documento
info:eu-repo/semantics/article
Versión
info:eu-repo/semantics/publishedVersion
Versión del editor
http://dx.doi.org/10.1016/S0957-4166(00)80162-7
Derechos
© Elsevier, 1993
Derechos de acceso
info:eu-repo/semantics/openAccess
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Abstract
The four stereoisomers of methyl tetrahydrofuran-2-ylmethyl 2,6-dimethyl-4-(o-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxilate (furnidipine), have been synthesized and separated by chiral chromatography using D-phenylglycine as chiral stationary phase. Enantiomeric purity of stereoisomers is determined by HPLC-CSP technique and configurations deduced via X-ray crystallography.
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