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dc.contributor.authorVillarroya, Mercedes
dc.contributor.authorGandía, Luis
dc.contributor.authorLópez, Manuela G.
dc.contributor.authorGarcía, Antonio G.
dc.contributor.authorCueto, Sénida
dc.contributor.authorGarcía Navío, José Luis 
dc.contributor.authorÁlvarez-Builla Gómez, Julio 
dc.date.accessioned2009-07-08T02:16:40Z
dc.date.available2009-07-08T02:16:40Z
dc.date.issued1996
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry, 1996, v.4, n.8, p.1177-1183en
dc.identifier.issn0968-0896
dc.identifier.urihttp://hdl.handle.net/10017/3513
dc.description.abstractTaking as models the polyamine toxin fraction FTX from the funnel-web spider venom, and the guanidinium moiety of guanethidine, a series of azaalkane-1,omega-diguanidinium salts were obtained. Some of them blocked ion fluxes through the neuronal nicotinic receptors for acetylcholine (nAChR). The blockade was exerted at submicromolar concentrations, suggesting a highly selective interaction with the nAChR. In fact, the active compounds on the nAChR ion channel did not recognize the voltage-dependent Na+ or Ca2+ channels of bovine adrenal chromaffin cells. Therefore, these compounds may be useful tools to clarify the functions of nAChR receptors in the central and peripheral nervous systems.en
dc.description.sponsorshipFundación Ramón Areceses_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherPergamonen
dc.rights© Elsevier, 1996en
dc.subjectBovine chromaffin cellsen
dc.subjectCalcium channelsen
dc.subjectFTXen
dc.subjectSeparationen
dc.subjectToxinen
dc.subjectBiochemistry & Molecular Biologyen
dc.titleSynthesis and pharmacology of alkanediguanidinium compounds that block the neuronal nicotinic acetylcholine receptoren
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaCIENCIAes_ES
dc.subject.ecienciaQuímica orgánicaes_ES
dc.subject.ecienciaSCIENCEen
dc.subject.ecienciaChemistry, organicen
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Química Orgánica
dc.relation.publisherversionhttp://dx.doi.org/10.1016/0968-0896(96)00108-3
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1016/0968-0896(96)00108-3
dc.relation.projectIDPM92-0039 (Ministerio de Educación y Ciencia)
dc.relation.projectIDPB94-0150 (Ministerio de Educación y Ciencia)
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen


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