dc.contributor.author | Villarroya, Mercedes | |
dc.contributor.author | Gandía, Luis | |
dc.contributor.author | López, Manuela G. | |
dc.contributor.author | García, Antonio G. | |
dc.contributor.author | Cueto, Sénida | |
dc.contributor.author | García Navío, José Luis | |
dc.contributor.author | Álvarez-Builla Gómez, Julio | |
dc.date.accessioned | 2009-07-08T02:16:40Z | |
dc.date.available | 2009-07-08T02:16:40Z | |
dc.date.issued | 1996 | |
dc.identifier.bibliographicCitation | Bioorganic & Medicinal Chemistry, 1996, v.4, n.8, p.1177-1183 | en |
dc.identifier.issn | 0968-0896 | |
dc.identifier.uri | http://hdl.handle.net/10017/3513 | |
dc.description.abstract | Taking as models the polyamine toxin fraction FTX from the funnel-web spider venom, and the guanidinium moiety of guanethidine, a series of azaalkane-1,omega-diguanidinium salts were obtained. Some of them blocked ion fluxes through the neuronal nicotinic receptors for acetylcholine (nAChR). The blockade was exerted at submicromolar concentrations, suggesting a highly selective interaction with the nAChR. In fact, the active compounds on the nAChR ion channel did not recognize the voltage-dependent Na+ or Ca2+ channels of bovine adrenal chromaffin cells. Therefore, these compounds may be useful tools to clarify the functions of nAChR receptors in the central and peripheral nervous systems. | en |
dc.description.sponsorship | Fundación Ramón Areces | es_ES |
dc.description.sponsorship | Ministerio de Educación y Ciencia | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Pergamon | en |
dc.rights | © Elsevier, 1996 | en |
dc.subject | Bovine chromaffin cells | en |
dc.subject | Calcium channels | en |
dc.subject | FTX | en |
dc.subject | Separation | en |
dc.subject | Toxin | en |
dc.subject | Biochemistry & Molecular Biology | en |
dc.title | Synthesis and pharmacology of alkanediguanidinium compounds that block the neuronal nicotinic acetylcholine receptor | en |
dc.type | info:eu-repo/semantics/article | en |
dc.subject.eciencia | Ciencia | es_ES |
dc.subject.eciencia | Química orgánica | es_ES |
dc.subject.eciencia | Science | en |
dc.subject.eciencia | Chemistry, organic | en |
dc.contributor.affiliation | Universidad de Alcalá. Departamento de Química Orgánica | |
dc.relation.publisherversion | http://dx.doi.org/10.1016/0968-0896(96)00108-3 | |
dc.type.version | info:eu-repo/semantics/publishedVersion | en |
dc.identifier.doi | 10.1016/0968-0896(96)00108-3 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//PM92-0039/ES/PLASTICIDAD DE LA CELULA CROMAFIN CO-CULTIVADA CON ASTROGLIA | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MEC//PB94-0150/ES | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |