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Synthesis of new azino fused benzimidazolium salts. A new family of DNA intercalating agents. l

dc.contributor.authorPastor Fernández, Joaquín
dc.contributor.authorSiro Herrero, Jorge G.
dc.contributor.authorGarcía Navío, José Luis 
dc.contributor.authorVaquero López, Juan J.
dc.contributor.authorRodrigo López, María Melia 
dc.contributor.authorBallesteros González, Milagros
dc.contributor.authorÁlvarez-Builla Gómez, Julio 
dc.date.accessioned2009-07-02T20:13:19Z
dc.date.available2009-07-02T20:13:19Z
dc.date.issued1995
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.5, n.24, p.3043-3048en
dc.identifier.issn0960-894X
dc.identifier.urihttp://hdl.handle.net/10017/3436
dc.description.abstractA series of new pyrido[1,2-a]- and pyridazino[1,6-a]benzimidazolium salts have been synthesized from readily available 1,3-disubstituted 2-alkylbenzimidazolium salts. Their affinity to DNA and in vitro cytotoxicity versus HT-29 have been tested. The initial results show that the title compounds are a new family of intercalating agents.en
dc.description.sponsorshipUniversidad de Alcaláes_ES
dc.description.sponsorshipComisión Interministerial de Ciencia y Tecnología-CICYTes_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherPergamonen
dc.rights© Elsevier, 1995en
dc.subjectWestphal condensationen
dc.subjectDeoxyribonucleic-aciden
dc.subjectDrugsen
dc.subjectDerivativesen
dc.subjectKineticsen
dc.subjectAnalogsen
dc.subjectChemistry, Medicinalen
dc.subjectChemistry, Organicen
dc.titleSynthesis of new azino fused benzimidazolium salts. A new family of DNA intercalating agents. len
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaCienciaes_ES
dc.subject.ecienciaQuímica orgánicaes_ES
dc.subject.ecienciaScienceen
dc.subject.ecienciaChemistry, organicen
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Química Orgánica
dc.relation.publisherversionhttp://dx.doi.org/10.1016/0960-894X(95)00532-4
dc.type.versioninfo:eu-repo/semantics/publishedVersionen
dc.identifier.doi10.1016/0960-894X(95)00532-4
dc.relation.projectIDinfo:eu-repo/grantAgreement/ICYT//SAF94-0280/ES/NUEVOS AGENTES BISINTERCALANTES SELECTIVOS SOBRE AONes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen


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