Improved synthesis of pyrrolo[1,2-c]pyrimidine and derivatives

Authors
Minguez Ortega, José Miguel; Vaquero López, Juan J.; García Navío, José LuisUniversity of Alcalá Author; Álvarez-Builla Gómez, JulioUniversity of Alcalá Author
Identifiers
Permanent link (URI): http://hdl.handle.net/10017/3427
DOI: 10.1016/0040-4039(96)00812-X
ISSN: 0040-4039
Publisher
Pergamon
Date
1996
Affiliation
Universidad de Alcalá. Departamento de Química Orgánica
Funders
We thank the Comissió Interdepartamental de Reserca i Innovació Tecnológica (CIRIT) for financial support (project QFN91-4619 ) and the Ministerio de Educación y Ciencia for a grant (J.M.M.)
Bibliographic citation
Tetrahedron Letters, v. 37, n. 24, p. 4263-4266
Keywords
Pyrrolo[1,2-c]pyrimidine
Project
QFN91-4619 (Comissió interdepartamental de Recerca i Innovació Tecnológica-CIRIT)
Document type
info:eu-repo/semantics/article
Version
info:eu-repo/semantics/publishedVersion
Publisher's version
http://dx.doi.org/10.1016/0040-4039(96)00812-X
Rights
(c) Elsevier, 1996
Access rights
info:eu-repo/semantics/openAccess
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Abstract
An improved synthesis of pyrrolo[1,2-c]pyrimidine derivatives by cyclocondensation of pyrrole-2-carboxaldehydes with tosylmethyl isocyanide followed by desulfonylation of the resulting 2-tosylpyrrolo[1,2-c]pyrimidines with sodium amalgam is described.
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