dc.contributor.author | Peña González, Cornelia Emeritina | |
dc.contributor.author | García Broncado, Pilar | |
dc.contributor.author | Ottaviani, M. Francesca | |
dc.contributor.author | Cangiotti, Michela | |
dc.contributor.author | Fattori, Alberto | |
dc.contributor.author | Hierro Oliva, Margarita | |
dc.contributor.author | González Martín, M. Luisa | |
dc.contributor.author | Pérez Serrano, Jorge | |
dc.contributor.author | Gómez Ramírez, Rafael | |
dc.contributor.author | Muñoz Fernández, María Ángeles | |
dc.contributor.author | Sánchez-Nieves Fernández, Javier | |
dc.contributor.author | Mata de la Mata, Francisco Javier de la | |
dc.date.accessioned | 2018-07-30T09:02:30Z | |
dc.date.available | 2018-07-30T09:02:30Z | |
dc.date.issued | 2016-02-01 | |
dc.identifier.bibliographicCitation | Chemistry - A European Journal, 2016, v. 22, n. 9, p. 2987-2999 | en |
dc.identifier.issn | 0947-6539 | |
dc.identifier.uri | http://hdl.handle.net/10017/34039 | |
dc.description.abstract | Anionic carbosilane dendrons decorated with sulfonate functions and with a thiol moiety at the focal point have been used to synthesize water soluble gold nanoparticles (AuNPs) by direct reaction of dendrons, gold precursor and reducing agent in water and also by place-exchange reaction. These nanoparticles have been characterized by nuclear magnetic resonance (NMR), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), UV, elemental analysis, and Z potential. Also, the interacting ability of the anionic sulfonate functions was investigated by electron paramagnetic resonance (EPR) using copper(II) as a probe. It was found that the different structures and conformations of the AuNPs modulate the availability of sulfonate and thiol groups to be complexed by copper(II). Toxicity assays of AuNPs showed that those produced by direct reaction were less toxic than those obtained by ligand exchange. Inhibition of HIV-1 infection was higher for dendronized AuNPs than for dendrons. | en |
dc.description.sponsorship | Ministerio de Economía y Empresa | es-ES |
dc.description.sponsorship | Comunidad de Madrid | es_ES |
dc.description.sponsorship | Universidad de Alcalá | es_ES |
dc.format.mimetype | application/pdf | en |
dc.language.iso | eng | en |
dc.publisher | Wiley | en |
dc.rights | Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0) | en |
dc.rights | (c) Wiley, 2016 | en |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.subject | Gold nanoparticles | en |
dc.subject | Sulfonate carbosilane dendrons | en |
dc.subject | Antivirus agents | en |
dc.subject | HIV | en |
dc.subject | EPR | en |
dc.title | Dendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activity | en |
dc.type | info:eu-repo/semantics/article | en |
dc.subject.eciencia | Química | es_ES |
dc.subject.eciencia | Chemistry | en |
dc.contributor.affiliation | Universidad de Alcalá. Departamento de Biomedicina y Biotecnología | es-ES |
dc.contributor.affiliation | Universidad de Alcalá. Departamento de Química Orgánica y Química Inorgánica | es-ES |
dc.date.updated | 2018-07-30T08:56:42Z | |
dc.type.version | info:eu-repo/semantics/acceptedVersion | en |
dc.identifier.doi | 10.1002 /chem .201504262 | |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//CTQ2011-23245/ES/DISEÑO DE NANOSISTEMAS DENDRÍTICOS BIFUNCIONALES DE NATURALEZA CARBOSILANO PARA SU APLICACIÓN EN BIOMEDICINA | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/MINECO//CTQ-2014-54004-P/ES/DISEÑO DE SISTEMAS DENDRÍTICOS AVANZADOS PARA SU USO EN BIOMEDICINA, OBTENIDOS A TRAVÉS DE PROCESOS DE DENDRONIZACIÓN | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/CAM//S2011%2FBMD-2351/ES/Nanosistemas Dendríticos para Aplicaciones Biomédicas - Dendritic Nanosystems for Biomedical Aplications | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/UE//PT13%2F0010%2F0028/UE/Plataforma de Biobancos | es_ES |
dc.relation.projectID | info:eu-repo/grantAgreement/UE//PI13%2F02016/UE/Desarrollo y mecanismo de acción de dendrimeros como microbicidas para frenar la infección por el VIH por transmisión sexual (vaginal y anal): Prueba de concepto | es_ES |
dc.rights.accessRights | info:eu-repo/semantics/openAccess | en |
dc.identifier.uxxi | AR/0000023081 | |
dc.identifier.publicationtitle | Chemistry - A European Journal | en |
dc.identifier.publicationvolume | 22 | |
dc.identifier.publicationlastpage | 2999 | |
dc.identifier.publicationissue | 9 | |
dc.identifier.publicationfirstpage | 2987 | |