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dc.contributor.authorPeña González, Cornelia Emeritina 
dc.contributor.authorGarcía Broncado, Pilar
dc.contributor.authorOttaviani, M. Francesca
dc.contributor.authorCangiotti, Michela
dc.contributor.authorFattori, Alberto
dc.contributor.authorHierro Oliva, Margarita
dc.contributor.authorGonzález Martín, M. Luisa
dc.contributor.authorPérez Serrano, Jorge 
dc.contributor.authorGómez Ramírez, Rafael 
dc.contributor.authorMuñoz Fernández, María Ángeles 
dc.contributor.authorSánchez-Nieves Fernández, Javier 
dc.contributor.authorMata de la Mata, Francisco Javier de la 
dc.date.accessioned2018-07-30T09:02:30Z
dc.date.available2018-07-30T09:02:30Z
dc.date.issued2016-02-01
dc.identifier.bibliographicCitationChemistry - A European Journal, 2016, v. 22, n. 9, p. 2987-2999en
dc.identifier.issn0947-6539
dc.identifier.urihttp://hdl.handle.net/10017/34039
dc.description.abstractAnionic carbosilane dendrons decorated with sulfonate functions and with a thiol moiety at the focal point have been used to synthesize water soluble gold nanoparticles (AuNPs) by direct reaction of dendrons, gold precursor and reducing agent in water and also by place-exchange reaction. These nanoparticles have been characterized by nuclear magnetic resonance (NMR), transmission electron microscopy (TEM), thermogravimetric analysis (TGA), X-ray photoelectron spectroscopy (XPS), UV, elemental analysis, and Z potential. Also, the interacting ability of the anionic sulfonate functions was investigated by electron paramagnetic resonance (EPR) using copper(II) as a probe. It was found that the different structures and conformations of the AuNPs modulate the availability of sulfonate and thiol groups to be complexed by copper(II). Toxicity assays of AuNPs showed that those produced by direct reaction were less toxic than those obtained by ligand exchange. Inhibition of HIV-1 infection was higher for dendronized AuNPs than for dendrons.en
dc.description.sponsorshipMinisterio de Economía y Empresaes-ES
dc.description.sponsorshipComunidad de Madrides_ES
dc.description.sponsorshipUniversidad de Alcaláes_ES
dc.format.mimetypeapplication/pdfen
dc.language.isoengen
dc.publisherWileyen
dc.rightsAttribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)en
dc.rights(c) Wiley, 2016en
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectGold nanoparticlesen
dc.subjectSulfonate carbosilane dendronsen
dc.subjectAntivirus agentsen
dc.subjectHIVen
dc.subjectEPRen
dc.titleDendronized Anionic Gold Nanoparticles: Synthesis, Characterization and Antiviral Activityen
dc.typeinfo:eu-repo/semantics/articleen
dc.subject.ecienciaQuímicaes_ES
dc.subject.ecienciaChemistryen
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Biomedicina y Biotecnologíaes-ES
dc.contributor.affiliationUniversidad de Alcalá. Departamento de Química Orgánica y Química Inorgánicaes-ES
dc.date.updated2018-07-30T08:56:42Z
dc.type.versioninfo:eu-repo/semantics/acceptedVersionen
dc.identifier.doi10.1002 /chem .201504262
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//CTQ2011-23245/ES/DISEÑO DE NANOSISTEMAS DENDRÍTICOS BIFUNCIONALES DE NATURALEZA CARBOSILANO PARA SU APLICACIÓN EN BIOMEDICINAes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/MINECO//CTQ-2014-54004-P/ES/DISEÑO DE SISTEMAS DENDRÍTICOS AVANZADOS PARA SU USO EN BIOMEDICINA, OBTENIDOS A TRAVÉS DE PROCESOS DE DENDRONIZACIÓNes_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/CAM//S2011%2FBMD-2351/ES/Nanosistemas Dendríticos para Aplicaciones Biomédicas - Dendritic Nanosystems for Biomedical Aplicationses_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/UE//PT13%2F0010%2F0028/UE/Plataforma de Biobancoses_ES
dc.relation.projectIDinfo:eu-repo/grantAgreement/UE//PI13%2F02016/UE/Desarrollo y mecanismo de acción de dendrimeros como microbicidas para frenar la infección por el VIH por transmisión sexual (vaginal y anal): Prueba de conceptoes_ES
dc.rights.accessRightsinfo:eu-repo/semantics/openAccessen
dc.identifier.uxxiAR/0000023081
dc.identifier.publicationtitleChemistry - A European Journalen
dc.identifier.publicationvolume22
dc.identifier.publicationlastpage2999
dc.identifier.publicationissue9
dc.identifier.publicationfirstpage2987


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